Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria
Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV),...
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2294859 |
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| author | Anise Nkenjop Happi Olusola Akinola Ogunsanya Akeemat Opeyemi Ayinla Ayotunde Elijah Sijuwola Femi Mudasiru Saibu Kazeem Akano Cecilia Nwofoke Obineche Tobias Elias Olivia Achonduh-Atijegbe Richard Olumide Daodu Oluwatobi Abel Adedokun Abraham Adeyemo Kehinde Ebenezer Ogundana Omolola Zaheedat Lawal Edyth Parker Iguosadolo Nosamiefan Johnson Okolie Zahra F. Parker Melanie D. McCauley Leigh Anne Eller Kara Lombardi Abdulwasiu Bolaji Tiamiyu Michael Iroezindu Edward Akinwale Thierry Lamare Fouapon Assedi Njatou Tsedal Mebrahtu Erica Broach Anastasia Zuppe Petra Prins Jenny Lay Mihret Amare Kayvon Modjarrad Natalie D. Collins Sandhya Vasan Cynthia Tucker Sharon Daye Christian Tientcha Happi |
| author_facet | Anise Nkenjop Happi Olusola Akinola Ogunsanya Akeemat Opeyemi Ayinla Ayotunde Elijah Sijuwola Femi Mudasiru Saibu Kazeem Akano Cecilia Nwofoke Obineche Tobias Elias Olivia Achonduh-Atijegbe Richard Olumide Daodu Oluwatobi Abel Adedokun Abraham Adeyemo Kehinde Ebenezer Ogundana Omolola Zaheedat Lawal Edyth Parker Iguosadolo Nosamiefan Johnson Okolie Zahra F. Parker Melanie D. McCauley Leigh Anne Eller Kara Lombardi Abdulwasiu Bolaji Tiamiyu Michael Iroezindu Edward Akinwale Thierry Lamare Fouapon Assedi Njatou Tsedal Mebrahtu Erica Broach Anastasia Zuppe Petra Prins Jenny Lay Mihret Amare Kayvon Modjarrad Natalie D. Collins Sandhya Vasan Cynthia Tucker Sharon Daye Christian Tientcha Happi |
| author_sort | Anise Nkenjop Happi |
| collection | DOAJ |
| description | Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from 2021–2022 in four locations in southern Nigeria with reported cases of Lassa fever (LF). Birds, lizards, and domestic mammals (dogs, pigs, cattle and goats) were screened using RT-qPCR, and whole genome sequencing was performed for lineage identification on selected LASV positive samples. Animals were also screened for exposure to LASV by enzyme-linked immunosorbent assay (ELISA). Among these animals, lizards had the highest positivity rate by PCR. Genomic sequencing of samples in most infected animals showed sub-lineage 2 g of LASV. Seropositivity was highest among cattle and lowest in pigs. Though the specific impact these additional hosts may have in the broader virus-host context are still unknown – specifically relating to pathogen diversity, evolution, and transmission – the detection of LASV in non-rodent hosts living in proximity to confirmed human LF cases suggests their involvement during transmission as potential reservoirs. Additional epidemiological data comparing viral genomes from humans and animals, as well as those circulating within the environment will be critical in understanding LASV transmission dynamics and will ultimately guide the development of countermeasures for this zoonotic health threat. |
| format | Article |
| id | doaj-art-3f94ef23e9a442aa9335d369ac1f2213 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-3f94ef23e9a442aa9335d369ac1f22132024-12-07T04:40:16ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2023.2294859Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern NigeriaAnise Nkenjop Happi0Olusola Akinola Ogunsanya1Akeemat Opeyemi Ayinla2Ayotunde Elijah Sijuwola3Femi Mudasiru Saibu4Kazeem Akano5Cecilia Nwofoke6Obineche Tobias Elias7Olivia Achonduh-Atijegbe8Richard Olumide Daodu9Oluwatobi Abel Adedokun10Abraham Adeyemo11Kehinde Ebenezer Ogundana12Omolola Zaheedat Lawal13Edyth Parker14Iguosadolo Nosamiefan15Johnson Okolie16Zahra F. Parker17Melanie D. McCauley18Leigh Anne Eller19Kara Lombardi20Abdulwasiu Bolaji Tiamiyu21Michael Iroezindu22Edward Akinwale23Thierry Lamare Fouapon Assedi Njatou24Tsedal Mebrahtu25Erica Broach26Anastasia Zuppe27Petra Prins28Jenny Lay29Mihret Amare30Kayvon Modjarrad31Natalie D. Collins32Sandhya Vasan33Cynthia Tucker34Sharon Daye35Christian Tientcha Happi36African Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAlex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, NigeriaUniversity of Nigeria, Nsukka, NigeriaAlex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaRedeemer’s University, Ede, Osun, NigeriaRedeemer’s University, Ede, Osun, NigeriaScripps Translational Science Institute, La Jolla, CA, USAAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, NigeriaHenry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, NigeriaHenry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, NigeriaOne Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAEmerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USAViral Diseases Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USAHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAOne Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USAOne Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USAAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, NigeriaIdentification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from 2021–2022 in four locations in southern Nigeria with reported cases of Lassa fever (LF). Birds, lizards, and domestic mammals (dogs, pigs, cattle and goats) were screened using RT-qPCR, and whole genome sequencing was performed for lineage identification on selected LASV positive samples. Animals were also screened for exposure to LASV by enzyme-linked immunosorbent assay (ELISA). Among these animals, lizards had the highest positivity rate by PCR. Genomic sequencing of samples in most infected animals showed sub-lineage 2 g of LASV. Seropositivity was highest among cattle and lowest in pigs. Though the specific impact these additional hosts may have in the broader virus-host context are still unknown – specifically relating to pathogen diversity, evolution, and transmission – the detection of LASV in non-rodent hosts living in proximity to confirmed human LF cases suggests their involvement during transmission as potential reservoirs. Additional epidemiological data comparing viral genomes from humans and animals, as well as those circulating within the environment will be critical in understanding LASV transmission dynamics and will ultimately guide the development of countermeasures for this zoonotic health threat.https://www.tandfonline.com/doi/10.1080/22221751.2023.2294859Lassa virusLASV genomesnon-rodentsanimalsNigeriaLASV lineages 2 g |
| spellingShingle | Anise Nkenjop Happi Olusola Akinola Ogunsanya Akeemat Opeyemi Ayinla Ayotunde Elijah Sijuwola Femi Mudasiru Saibu Kazeem Akano Cecilia Nwofoke Obineche Tobias Elias Olivia Achonduh-Atijegbe Richard Olumide Daodu Oluwatobi Abel Adedokun Abraham Adeyemo Kehinde Ebenezer Ogundana Omolola Zaheedat Lawal Edyth Parker Iguosadolo Nosamiefan Johnson Okolie Zahra F. Parker Melanie D. McCauley Leigh Anne Eller Kara Lombardi Abdulwasiu Bolaji Tiamiyu Michael Iroezindu Edward Akinwale Thierry Lamare Fouapon Assedi Njatou Tsedal Mebrahtu Erica Broach Anastasia Zuppe Petra Prins Jenny Lay Mihret Amare Kayvon Modjarrad Natalie D. Collins Sandhya Vasan Cynthia Tucker Sharon Daye Christian Tientcha Happi Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria Emerging Microbes and Infections Lassa virus LASV genomes non-rodents animals Nigeria LASV lineages 2 g |
| title | Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria |
| title_full | Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria |
| title_fullStr | Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria |
| title_full_unstemmed | Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria |
| title_short | Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria |
| title_sort | lassa virus in novel hosts insights into the epidemiology of lassa virus infections in southern nigeria |
| topic | Lassa virus LASV genomes non-rodents animals Nigeria LASV lineages 2 g |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2294859 |
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