The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study
Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases. However, no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on cardiometabolic health, gut microbiota, and psych...
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250038 |
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| author | Jiehua Chen Ruijie Zhang Chao Zhou Louise Weiwei Lu Dana Feng Haiqiao Zou Ran Gao Xinying Zhang Peiyi Chen Jiayue Zhu Haoxie Xu Nina Zeng Cijuan Zhang Bin Liu Mingfu Wang Qian Ge Caiqun Ouyang Feng Chen |
| author_facet | Jiehua Chen Ruijie Zhang Chao Zhou Louise Weiwei Lu Dana Feng Haiqiao Zou Ran Gao Xinying Zhang Peiyi Chen Jiayue Zhu Haoxie Xu Nina Zeng Cijuan Zhang Bin Liu Mingfu Wang Qian Ge Caiqun Ouyang Feng Chen |
| author_sort | Jiehua Chen |
| collection | DOAJ |
| description | Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases. However, no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on cardiometabolic health, gut microbiota, and psychological status in healthy people. A 4-week step-wise misaligned-realigned controlled-feeding trial with a 2 × 2 factorial design (sleep and diet) was conducted on healthy young adults. At first, subjects experienced a one-week circadian rhythm misalignment with a high-fat fast-food diet, extended eating window, and delayed sleep schedules, then gradually transited to a complete circadian rhythm realignment with a high-fiber balanced diet, 8-h time-restricted eating, and normal sleep schedules. Circadian rhythm misalignment led to significantly higher levels of fasting glucose and homeostatic model assessment for insulin resistance (HOMA-IR) of subjects compared to baseline and failed to recover to the baseline level in circadian rhythm realignments. Notably, the incremental area under the curve (iAUC) of postprandial glucose decreased with circadian rhythm adjustments as compared to that in circadian rhythm misalignment, suggesting circadian rhythm realignment by sleep or/and diet could partly restore glucose metabolism impaired by a short-term circadian rhythm misalignment. However, circadian rhythm changes did not result in overall perturbations of gut microbiota diversities. |
| format | Article |
| id | doaj-art-3f824475f15b4e30b70a6643cf5bc1f0 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-3f824475f15b4e30b70a6643cf5bc1f02025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363553356910.26599/FSHW.2023.9250038The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding studyJiehua Chen0Ruijie Zhang1Chao Zhou2Louise Weiwei Lu3Dana Feng4Haiqiao Zou5Ran Gao6Xinying Zhang7Peiyi Chen8Jiayue Zhu9Haoxie Xu10Nina Zeng11Cijuan Zhang12Bin Liu13Mingfu Wang14Qian Ge15Caiqun Ouyang16Feng Chen17Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaDepartment of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Biological Sciences, University of Auckland, Auckland 1010, New ZealandDepartment of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaFood Quality and Design Group, Wageningen University & Research, Wageningen 6700 AA, NetherlandsInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaDepartment of Orthopaedics, North Shore Hospital, Auckland 0620, New ZealandDepartment of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaDepartment of Nutrition, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, ChinaDepartment of Nutrition, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, ChinaInstitute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, ChinaEpidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases. However, no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on cardiometabolic health, gut microbiota, and psychological status in healthy people. A 4-week step-wise misaligned-realigned controlled-feeding trial with a 2 × 2 factorial design (sleep and diet) was conducted on healthy young adults. At first, subjects experienced a one-week circadian rhythm misalignment with a high-fat fast-food diet, extended eating window, and delayed sleep schedules, then gradually transited to a complete circadian rhythm realignment with a high-fiber balanced diet, 8-h time-restricted eating, and normal sleep schedules. Circadian rhythm misalignment led to significantly higher levels of fasting glucose and homeostatic model assessment for insulin resistance (HOMA-IR) of subjects compared to baseline and failed to recover to the baseline level in circadian rhythm realignments. Notably, the incremental area under the curve (iAUC) of postprandial glucose decreased with circadian rhythm adjustments as compared to that in circadian rhythm misalignment, suggesting circadian rhythm realignment by sleep or/and diet could partly restore glucose metabolism impaired by a short-term circadian rhythm misalignment. However, circadian rhythm changes did not result in overall perturbations of gut microbiota diversities.https://www.sciopen.com/article/10.26599/FSHW.2023.9250038circadian rhythmglucose metabolismgut microbiotadietary patternssleep schedulepsychological status |
| spellingShingle | Jiehua Chen Ruijie Zhang Chao Zhou Louise Weiwei Lu Dana Feng Haiqiao Zou Ran Gao Xinying Zhang Peiyi Chen Jiayue Zhu Haoxie Xu Nina Zeng Cijuan Zhang Bin Liu Mingfu Wang Qian Ge Caiqun Ouyang Feng Chen The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study Food Science and Human Wellness circadian rhythm glucose metabolism gut microbiota dietary patterns sleep schedule psychological status |
| title | The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study |
| title_full | The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study |
| title_fullStr | The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study |
| title_full_unstemmed | The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study |
| title_short | The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study |
| title_sort | impact of short term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults a proof of concept controlled feeding study |
| topic | circadian rhythm glucose metabolism gut microbiota dietary patterns sleep schedule psychological status |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250038 |
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