Association of lipid accumulation product with mortality in patients with diabetes mellitus
Abstract Lipid accumulation product (LAP) is associated with increased risk of metabolic diseases and cardiovascular disease. However, its relationship with all-cause mortality and cardiovascular mortality among diabetes mellitus (DM) patients remains unclear. This study aims to explore the associat...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-04861-0 |
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| author | Deng Pan Pengfei Chen Siyan Ji He Zhang Tielong Chen |
| author_facet | Deng Pan Pengfei Chen Siyan Ji He Zhang Tielong Chen |
| author_sort | Deng Pan |
| collection | DOAJ |
| description | Abstract Lipid accumulation product (LAP) is associated with increased risk of metabolic diseases and cardiovascular disease. However, its relationship with all-cause mortality and cardiovascular mortality among diabetes mellitus (DM) patients remains unclear. This study aims to explore the associations between LAP and mortality outcomes in patients with DM. This study included 10,944 patients with DM from the national health and nutrition examination survey. LAP was calculated using waist circumference and triglyceride levels, according to gender-specific formula. All-cause and cardiovascular mortality were determined through linkage with the national death index database through December 31, 2019. Multivariable Cox proportional hazard models examined the associations between LAP and mortality. Restricted cubic splines were used to investigate potential non-linear relationships. A series of subgroup and sensitivity analyses were also performed to evaluate robustness of our results. During a median follow-up of 86 months, 1,508 all-cause deaths and 413 cardiovascular deaths were recorded. Higher LAP levels were associated with an increased risk of both all-cause mortality (highest vs. lowest quartile: hazard ratio [HR] 1.69, 95% CI 1.39–2.05) and cardiovascular mortality (HR 2.02, 95% CI 1.36–3.00). Non-linear relationships were observed between LAP and both all-cause and cardiovascular mortality. Notably, interactions between LAP and both age and diabetes duration were found in relation to all-cause and cardiovascular mortality. The results remained consistent after a series of subgroup and sensitivity analyses. The results didn’t significantly change according to a series of subgroup and sensitivity analyses. Higher LAP levels were associated with increased risks of all-cause and cardiovascular mortality in patients with DM. These findings suggest that LAP could serve as a valuable predictor for mortality risk assessment in diabetic patients. |
| format | Article |
| id | doaj-art-3f7d02a3eb1b4a34b6f58b41964e8c95 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-3f7d02a3eb1b4a34b6f58b41964e8c952025-08-20T04:01:24ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-04861-0Association of lipid accumulation product with mortality in patients with diabetes mellitusDeng Pan0Pengfei Chen1Siyan Ji2He Zhang3Tielong Chen4Hangzhou Hospital of Traditional Chinese MedicineXiyuan Hospital of China Academy of Chinese Medical SciencesStomatology Department of Qiqihar Medical College SchoolXiyuan Hospital of China Academy of Chinese Medical SciencesHangzhou Hospital of Traditional Chinese MedicineAbstract Lipid accumulation product (LAP) is associated with increased risk of metabolic diseases and cardiovascular disease. However, its relationship with all-cause mortality and cardiovascular mortality among diabetes mellitus (DM) patients remains unclear. This study aims to explore the associations between LAP and mortality outcomes in patients with DM. This study included 10,944 patients with DM from the national health and nutrition examination survey. LAP was calculated using waist circumference and triglyceride levels, according to gender-specific formula. All-cause and cardiovascular mortality were determined through linkage with the national death index database through December 31, 2019. Multivariable Cox proportional hazard models examined the associations between LAP and mortality. Restricted cubic splines were used to investigate potential non-linear relationships. A series of subgroup and sensitivity analyses were also performed to evaluate robustness of our results. During a median follow-up of 86 months, 1,508 all-cause deaths and 413 cardiovascular deaths were recorded. Higher LAP levels were associated with an increased risk of both all-cause mortality (highest vs. lowest quartile: hazard ratio [HR] 1.69, 95% CI 1.39–2.05) and cardiovascular mortality (HR 2.02, 95% CI 1.36–3.00). Non-linear relationships were observed between LAP and both all-cause and cardiovascular mortality. Notably, interactions between LAP and both age and diabetes duration were found in relation to all-cause and cardiovascular mortality. The results remained consistent after a series of subgroup and sensitivity analyses. The results didn’t significantly change according to a series of subgroup and sensitivity analyses. Higher LAP levels were associated with increased risks of all-cause and cardiovascular mortality in patients with DM. These findings suggest that LAP could serve as a valuable predictor for mortality risk assessment in diabetic patients.https://doi.org/10.1038/s41598-025-04861-0Lipid accumulation productDiabetes mellitusMortalityNHANES |
| spellingShingle | Deng Pan Pengfei Chen Siyan Ji He Zhang Tielong Chen Association of lipid accumulation product with mortality in patients with diabetes mellitus Scientific Reports Lipid accumulation product Diabetes mellitus Mortality NHANES |
| title | Association of lipid accumulation product with mortality in patients with diabetes mellitus |
| title_full | Association of lipid accumulation product with mortality in patients with diabetes mellitus |
| title_fullStr | Association of lipid accumulation product with mortality in patients with diabetes mellitus |
| title_full_unstemmed | Association of lipid accumulation product with mortality in patients with diabetes mellitus |
| title_short | Association of lipid accumulation product with mortality in patients with diabetes mellitus |
| title_sort | association of lipid accumulation product with mortality in patients with diabetes mellitus |
| topic | Lipid accumulation product Diabetes mellitus Mortality NHANES |
| url | https://doi.org/10.1038/s41598-025-04861-0 |
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