Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients
Lyell’s syndrome or Toxic Epidermal Necrolysis (TEN) is a rare and life-threatening dermatological disease. Most commonly, this syndrome is drug-induced, and is a result of an immune-allergic reaction to medications. Anti-cancer drugs were not the most frequent groups of therapeutic agents related t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/11/509 |
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| author | Julie Coussirou Magali Ravoire Alma Stancu Léa Vazquez |
| author_facet | Julie Coussirou Magali Ravoire Alma Stancu Léa Vazquez |
| author_sort | Julie Coussirou |
| collection | DOAJ |
| description | Lyell’s syndrome or Toxic Epidermal Necrolysis (TEN) is a rare and life-threatening dermatological disease. Most commonly, this syndrome is drug-induced, and is a result of an immune-allergic reaction to medications. Anti-cancer drugs were not the most frequent groups of therapeutic agents related to Lyell’s syndrome, but the emergence of new therapeutic classes, particularly targeted therapy and immunotherapy, is changing current data. We present two cases of Lyell’s syndrome induced by anticancer drugs. (1) TEN in a man treated for metastatic urothelial carcinoma with Enfortumab Vedotin. (2) TEN in a man with metastatic melanoma treated with Nivolumab and Ipilimumab. Despite quick medical treatment and transfer to a severe burn unit, both patients died of TEN. |
| format | Article |
| id | doaj-art-3f51008f52e64cdf91d66f1ecc1510b0 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-3f51008f52e64cdf91d66f1ecc1510b02024-11-26T17:58:56ZengMDPI AGCurrent Oncology1198-00521718-77292024-11-0131116891689710.3390/curroncol31110509Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two PatientsJulie Coussirou0Magali Ravoire1Alma Stancu2Léa Vazquez3Institut du Cancer Avignon Provence, 250 Chemin de Baigne-Pieds, 84000 Avignon, FranceInstitut du Cancer Avignon Provence, 250 Chemin de Baigne-Pieds, 84000 Avignon, FranceInstitut du Cancer Avignon Provence, 250 Chemin de Baigne-Pieds, 84000 Avignon, FranceInstitut du Cancer Avignon Provence, 250 Chemin de Baigne-Pieds, 84000 Avignon, FranceLyell’s syndrome or Toxic Epidermal Necrolysis (TEN) is a rare and life-threatening dermatological disease. Most commonly, this syndrome is drug-induced, and is a result of an immune-allergic reaction to medications. Anti-cancer drugs were not the most frequent groups of therapeutic agents related to Lyell’s syndrome, but the emergence of new therapeutic classes, particularly targeted therapy and immunotherapy, is changing current data. We present two cases of Lyell’s syndrome induced by anticancer drugs. (1) TEN in a man treated for metastatic urothelial carcinoma with Enfortumab Vedotin. (2) TEN in a man with metastatic melanoma treated with Nivolumab and Ipilimumab. Despite quick medical treatment and transfer to a severe burn unit, both patients died of TEN.https://www.mdpi.com/1718-7729/31/11/509toxic epidermal necrolysisLyell’s syndromeenfortumab vedotinnivolumabpharmacovigilance |
| spellingShingle | Julie Coussirou Magali Ravoire Alma Stancu Léa Vazquez Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients Current Oncology toxic epidermal necrolysis Lyell’s syndrome enfortumab vedotin nivolumab pharmacovigilance |
| title | Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients |
| title_full | Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients |
| title_fullStr | Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients |
| title_full_unstemmed | Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients |
| title_short | Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients |
| title_sort | anti cancer drug induced lyell s syndrome a series of two patients |
| topic | toxic epidermal necrolysis Lyell’s syndrome enfortumab vedotin nivolumab pharmacovigilance |
| url | https://www.mdpi.com/1718-7729/31/11/509 |
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