The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim
Abstract Neuromusculoskeletal injuries including osteoarthritis, stroke, spinal cord injury, and traumatic brain injury affect roughly 19% of the U.S. adult population. Standardized interventions have produced suboptimal functional outcomes due to the unique treatment needs of each patient. Strides...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Journal of NeuroEngineering and Rehabilitation |
| Online Access: | https://doi.org/10.1186/s12984-025-01629-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325943590486016 |
|---|---|
| author | Claire V. Hammond Spencer T. Williams Marleny M. Vega Di Ao Geng Li Robert M. Salati Kayla M. Pariser Mohammad S. Shourijeh Ayman W. Habib Carolynn Patten Benjamin J. Fregly |
| author_facet | Claire V. Hammond Spencer T. Williams Marleny M. Vega Di Ao Geng Li Robert M. Salati Kayla M. Pariser Mohammad S. Shourijeh Ayman W. Habib Carolynn Patten Benjamin J. Fregly |
| author_sort | Claire V. Hammond |
| collection | DOAJ |
| description | Abstract Neuromusculoskeletal injuries including osteoarthritis, stroke, spinal cord injury, and traumatic brain injury affect roughly 19% of the U.S. adult population. Standardized interventions have produced suboptimal functional outcomes due to the unique treatment needs of each patient. Strides have been made to utilize computational models to develop personalized treatments, but researchers and clinicians have yet to cross the “valley of death” between fundamental research and clinical usefulness. This article introduces the Neuromusculoskeletal Modeling (NMSM) Pipeline, two MATLAB-based toolsets that add Model Personalization and Treatment Optimization functionality to OpenSim. The two toolsets facilitate computational design of individualized treatments for neuromusculoskeletal impairments through the use of personalized neuromusculoskeletal models and predictive simulation. The Model Personalization toolset contains four tools for personalizing 1) joint structure models, 2) muscle–tendon models, 3) neural control models, and 4) foot–ground contact models. The Treatment Optimization toolset contains three tools for predicting and optimizing a patient’s functional outcome for different treatment options using a patient’s personalized neuromusculoskeletal model and direct collocation optimal control methods. Support for user-defined cost, constraint, and model modification functions facilitate simulation of a vast number of possible treatments. An NMSM Pipeline use case is presented for an individual post-stroke with impaired walking function, where the goal was to predict how the subject’s neural control could be changed to improve walking speed without increasing metabolic cost. First the Model Personalization toolset was used to develop a personalized neuromusculoskeletal model of the subject starting from a generic OpenSim full-body model and experimental walking data (video motion capture, ground reaction, and electromyography) collected from the subject at his self-selected speed. Next the Treatment Optimization toolset was used with the personalized model to predict how the subject could recruit existing muscle synergies more effectively to reduce muscle activation disparities between the paretic and non-paretic legs. The software predicted that the subject could increase his walking speed by 60% without increasing his metabolic cost per unit time by modifying existing muscle synergy recruitment. This hypothetical treatment demonstrates how NMSM Pipeline tools could allow researchers working collaboratively with clinicians to develop personalized neuromusculoskeletal models of individual patients and to perform predictive simulations for designing personalized treatments that maximize a patient’s post-treatment functional outcome. |
| format | Article |
| id | doaj-art-3f4fc08d86cb4f6883f686e87f8dbca7 |
| institution | Kabale University |
| issn | 1743-0003 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of NeuroEngineering and Rehabilitation |
| spelling | doaj-art-3f4fc08d86cb4f6883f686e87f8dbca72025-08-20T03:48:15ZengBMCJournal of NeuroEngineering and Rehabilitation1743-00032025-05-0122112810.1186/s12984-025-01629-5The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSimClaire V. Hammond0Spencer T. Williams1Marleny M. Vega2Di Ao3Geng Li4Robert M. Salati5Kayla M. Pariser6Mohammad S. Shourijeh7Ayman W. Habib8Carolynn Patten9Benjamin J. Fregly10Department of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Mechanical Engineering, Rice UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Physical Medicine and Rehabilitation, UC Davis School of MedicineDepartment of Mechanical Engineering, Rice UniversityAbstract Neuromusculoskeletal injuries including osteoarthritis, stroke, spinal cord injury, and traumatic brain injury affect roughly 19% of the U.S. adult population. Standardized interventions have produced suboptimal functional outcomes due to the unique treatment needs of each patient. Strides have been made to utilize computational models to develop personalized treatments, but researchers and clinicians have yet to cross the “valley of death” between fundamental research and clinical usefulness. This article introduces the Neuromusculoskeletal Modeling (NMSM) Pipeline, two MATLAB-based toolsets that add Model Personalization and Treatment Optimization functionality to OpenSim. The two toolsets facilitate computational design of individualized treatments for neuromusculoskeletal impairments through the use of personalized neuromusculoskeletal models and predictive simulation. The Model Personalization toolset contains four tools for personalizing 1) joint structure models, 2) muscle–tendon models, 3) neural control models, and 4) foot–ground contact models. The Treatment Optimization toolset contains three tools for predicting and optimizing a patient’s functional outcome for different treatment options using a patient’s personalized neuromusculoskeletal model and direct collocation optimal control methods. Support for user-defined cost, constraint, and model modification functions facilitate simulation of a vast number of possible treatments. An NMSM Pipeline use case is presented for an individual post-stroke with impaired walking function, where the goal was to predict how the subject’s neural control could be changed to improve walking speed without increasing metabolic cost. First the Model Personalization toolset was used to develop a personalized neuromusculoskeletal model of the subject starting from a generic OpenSim full-body model and experimental walking data (video motion capture, ground reaction, and electromyography) collected from the subject at his self-selected speed. Next the Treatment Optimization toolset was used with the personalized model to predict how the subject could recruit existing muscle synergies more effectively to reduce muscle activation disparities between the paretic and non-paretic legs. The software predicted that the subject could increase his walking speed by 60% without increasing his metabolic cost per unit time by modifying existing muscle synergy recruitment. This hypothetical treatment demonstrates how NMSM Pipeline tools could allow researchers working collaboratively with clinicians to develop personalized neuromusculoskeletal models of individual patients and to perform predictive simulations for designing personalized treatments that maximize a patient’s post-treatment functional outcome.https://doi.org/10.1186/s12984-025-01629-5 |
| spellingShingle | Claire V. Hammond Spencer T. Williams Marleny M. Vega Di Ao Geng Li Robert M. Salati Kayla M. Pariser Mohammad S. Shourijeh Ayman W. Habib Carolynn Patten Benjamin J. Fregly The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim Journal of NeuroEngineering and Rehabilitation |
| title | The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim |
| title_full | The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim |
| title_fullStr | The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim |
| title_full_unstemmed | The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim |
| title_short | The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim |
| title_sort | neuromusculoskeletal modeling pipeline matlab based model personalization and treatment optimization functionality for opensim |
| url | https://doi.org/10.1186/s12984-025-01629-5 |
| work_keys_str_mv | AT clairevhammond theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT spencertwilliams theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT marlenymvega theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT diao theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT gengli theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT robertmsalati theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT kaylampariser theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT mohammadsshourijeh theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT aymanwhabib theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT carolynnpatten theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT benjaminjfregly theneuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT clairevhammond neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT spencertwilliams neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT marlenymvega neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT diao neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT gengli neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT robertmsalati neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT kaylampariser neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT mohammadsshourijeh neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT aymanwhabib neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT carolynnpatten neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim AT benjaminjfregly neuromusculoskeletalmodelingpipelinematlabbasedmodelpersonalizationandtreatmentoptimizationfunctionalityforopensim |