Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions
Objective: The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and –20 °C. Method: Blood samples of patients treated with trastuzumab (Herceptin ®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-03-01
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| Series: | Farmacia Hospitalaria |
| Subjects: | |
| Online Access: | http://www.aulamedica.es/fh/pdf/11110.pdf |
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| Summary: | Objective: The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and –20 °C.
Method: Blood samples of patients treated with trastuzumab (Herceptin ®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood plasma stored at 4 °C during 120 hours and blood plasma stored at –20 °C during 365 days.
Results: In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The concentration of trastuzumab was 95.22 ± 3.20% after 12 months’ storage at –20 ºC.
Conclusions: The concentration of trastuzumab remains stable for at least 72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C and one year in plasma stored at –20 °C. |
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| ISSN: | 1130-6343 2171-8695 |