Differential modulation of inflammatory cytokines by recombinant IL-10 in IL-1β and TNF-α ̶ stimulated equine chondrocytes and synoviocytes: impact of washing and timing on cytokine responses

Differential modulation of inflammatory cytokines by recombinant IL-10 in IL-1β and TNF-α ̶ stimulated equine chondrocytes and synoviocytes: impact of washing and timing on cytokine responses

Abstract Osteoarthritis (OA) remains a challenging joint disorder necessitating effective anti-inflammatory interventions. In this study, our primary objective was to establish an in vitro protocol that replicates the clinical investigation of anti-inflammatory drugs intended for OA management. Focu...

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Bibliographic Details
Main Authors: Hoda A. Elkhenany, Renata L. Linardi, Kyla F. Ortved
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Veterinary Research
Subjects:
Drug screening
Interleukin-10
Osteoarthritis
Translational research
Inflammatory cytokines
Online Access:https://doi.org/10.1186/s12917-024-04403-2
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