PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck
Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow‐up of 4–14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki‐67, p53, bcl‐2 and presence of mutations in the p53 gene. The tumour site was not associat...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/1997/591251 |
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| _version_ | 1841524714052255744 |
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| author | Karin Nylander Elsy‐Britt Schildt Mikael Eriksson Göran Roos |
| author_facet | Karin Nylander Elsy‐Britt Schildt Mikael Eriksson Göran Roos |
| author_sort | Karin Nylander |
| collection | DOAJ |
| description | Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow‐up of 4–14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki‐67, p53, bcl‐2 and presence of mutations in the p53 gene. The tumour site was not associated with the different parameters calculated. PCNA and Ki‐67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl‐2 positivity was detected in a minor fraction (10%) of the tumours. |
| format | Article |
| id | doaj-art-3f185a6eaf684768a05861e1a0a61810 |
| institution | Kabale University |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-3f185a6eaf684768a05861e1a0a618102025-02-03T05:47:32ZengWileyAnalytical Cellular Pathology0921-89121878-36511997-01-0114210111010.1155/1997/591251PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and NeckKarin Nylander0Elsy‐Britt Schildt1Mikael Eriksson2Göran Roos3Department of Pathology, Umeå University, S‐901 87 Umeå, SwedenDepartment of Oncology, Umeå University, S‐901 87 Umeå, SwedenDepartment of Oncology, Umeå University, S‐901 87 Umeå, SwedenDepartment of Pathology, Umeå University, S‐901 87 Umeå, SwedenEighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow‐up of 4–14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki‐67, p53, bcl‐2 and presence of mutations in the p53 gene. The tumour site was not associated with the different parameters calculated. PCNA and Ki‐67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl‐2 positivity was detected in a minor fraction (10%) of the tumours.http://dx.doi.org/10.1155/1997/591251 |
| spellingShingle | Karin Nylander Elsy‐Britt Schildt Mikael Eriksson Göran Roos PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck Analytical Cellular Pathology |
| title | PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck |
| title_full | PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck |
| title_fullStr | PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck |
| title_full_unstemmed | PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck |
| title_short | PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck |
| title_sort | pcna ki 67 p53 bcl 2 and prognosis in intraoral squamous cell carcinoma of the head and neck |
| url | http://dx.doi.org/10.1155/1997/591251 |
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