Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review
Head and neck cancer is the 7th most common malignancy worldwide. Few decades earlier, there has been an enormous rise in genetic events as the source in the development of Oral Squamous Cell Carcinoma (OSCC) and metastasis to various organs. The seeding of neoplastic cells occurs via blood vessels...
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JCDR Research and Publications Private Limited
2024-12-01
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| author | Niva Mahapatra S Nithya Divya Uppala Soundarya Srinivasan Daffney Mano Doss |
| author_facet | Niva Mahapatra S Nithya Divya Uppala Soundarya Srinivasan Daffney Mano Doss |
| author_sort | Niva Mahapatra |
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| description | Head and neck cancer is the 7th most common malignancy worldwide. Few decades earlier, there has been an enormous rise in genetic events as the source in the development of Oral Squamous Cell Carcinoma (OSCC) and metastasis to various organs. The seeding of neoplastic cells occurs via blood vessels (haematogenous spread), lymphatics (lymphogenous spread), or invasion into body cavities (transcoelomic spread). Neoangiogenesis results in haematogenous spread from the site of the primary tumour. Various angiogenic markers have been recognised, like Vascular Endothelial Growth Factor (VEGF), Angiopoietin-1 (Ang-1), Ang-2, Cluster of Differentiation (CD34), in head and neck neoplasms. The specificity and sensitivity of CD34 helps in vascular endothelial cell staining. CD34 is a type I transmembrane molecule of 110 kDa that is heavily glycosylated and expressed on haematopoietic progenitor cells selectively. The quantification of new blood vessels using CD34 antibody by Microvessel Density (MVD) can be used as a diagnostic and therapeutic indicator in many solid malignancies, like OSCC. Increased expression of positive CD34 antibody induces neoangiogenesis in neoplasms, upsurges the stemness of cancer and boosts its potential to metastasise. In this context, the present review focuses on use of CD34 antibody as a potential angiogenic marker that can be used to determine the the aggressiveness and potential outcome of the tumour based on the literature overview. |
| format | Article |
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| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-3f024fc9d0b34381b4c88dfe84f3c88c2024-12-10T11:04:49ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-12-011812010410.7860/JCDR/2024/74349.20367Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative ReviewNiva Mahapatra0S Nithya1Divya Uppala2Soundarya Srinivasan3Daffney Mano Doss4Reader, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India.Assistant Professor, Department of Oral and Maxillofacial Pathology, ESIC Dental College and Hospital, New Delhi, India.Professor and Head, Department of Oral and Maxillofacial Pathology, GITAM Dental College, Vizag, Andhra Pradesh, India.Reader, Department of Oral and Maxillofacial Pathology, Best Dental Science College and Hospital, Madurai, Tamil Nadu, India.Lecturer, Department of Oral and Maxillofacial Pathology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India.Head and neck cancer is the 7th most common malignancy worldwide. Few decades earlier, there has been an enormous rise in genetic events as the source in the development of Oral Squamous Cell Carcinoma (OSCC) and metastasis to various organs. The seeding of neoplastic cells occurs via blood vessels (haematogenous spread), lymphatics (lymphogenous spread), or invasion into body cavities (transcoelomic spread). Neoangiogenesis results in haematogenous spread from the site of the primary tumour. Various angiogenic markers have been recognised, like Vascular Endothelial Growth Factor (VEGF), Angiopoietin-1 (Ang-1), Ang-2, Cluster of Differentiation (CD34), in head and neck neoplasms. The specificity and sensitivity of CD34 helps in vascular endothelial cell staining. CD34 is a type I transmembrane molecule of 110 kDa that is heavily glycosylated and expressed on haematopoietic progenitor cells selectively. The quantification of new blood vessels using CD34 antibody by Microvessel Density (MVD) can be used as a diagnostic and therapeutic indicator in many solid malignancies, like OSCC. Increased expression of positive CD34 antibody induces neoangiogenesis in neoplasms, upsurges the stemness of cancer and boosts its potential to metastasise. In this context, the present review focuses on use of CD34 antibody as a potential angiogenic marker that can be used to determine the the aggressiveness and potential outcome of the tumour based on the literature overview.https://www.jcdr.net/articles/PDF/20367/74349_CE[Ra1]_F(SL)_QC(SD_IS)_PF1(RI_SS)_PFA(IS)_PN(IS).pdfcluster of differentiationhead and neck carcinomamalignancymetastasismicrovessel densityneoangiogenesis |
| spellingShingle | Niva Mahapatra S Nithya Divya Uppala Soundarya Srinivasan Daffney Mano Doss Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review Journal of Clinical and Diagnostic Research cluster of differentiation head and neck carcinoma malignancy metastasis microvessel density neoangiogenesis |
| title | Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review |
| title_full | Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review |
| title_fullStr | Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review |
| title_full_unstemmed | Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review |
| title_short | Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review |
| title_sort | prognostic significance and therapeutic implications of cd34 an angiogenic marker in oral squamous cell carcinoma a narrative review |
| topic | cluster of differentiation head and neck carcinoma malignancy metastasis microvessel density neoangiogenesis |
| url | https://www.jcdr.net/articles/PDF/20367/74349_CE[Ra1]_F(SL)_QC(SD_IS)_PF1(RI_SS)_PFA(IS)_PN(IS).pdf |
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