Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus
The study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from Passiflora edulis fo. flavicarpa, for Type 1 Diabetes mellitus (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006418 |
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| author | Bárbara Cabral Ony Araújo Galdino Iago de Souza Gomes Jovelina Samara Ferreira Alves José Ivan Marques Karla Simone Costa de Souza Rodrigo Moreira da Silva Bento João Abreu Norberto Peporine Lopes Silvana Maria Zucolotto Adriana Augusto de Rezende |
| author_facet | Bárbara Cabral Ony Araújo Galdino Iago de Souza Gomes Jovelina Samara Ferreira Alves José Ivan Marques Karla Simone Costa de Souza Rodrigo Moreira da Silva Bento João Abreu Norberto Peporine Lopes Silvana Maria Zucolotto Adriana Augusto de Rezende |
| author_sort | Bárbara Cabral |
| collection | DOAJ |
| description | The study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from Passiflora edulis fo. flavicarpa, for Type 1 Diabetes mellitus (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the extracts (2000 mg/kg, orally) were safe. Liquid chromatography coupled to triple quadrupole mass spectrometry (LC-QqQ-MS/MS) identified five C-glycosylated flavonoids (vicenin-2, orientin, isoorientin, vitexin, isovitexin) in the extracts. Adjuvant treatment with extracts alongside insulin significantly improved glycemic control over 60 days compared to insulin alone (p < 0.05). Furthermore, extracts protected against renal fibrosis and maintenance of the levels of inflammatory markers, such as myeloperoxidase, in the hearts and kidneys of diabetic rats. These findings suggest passion fruit peel extracts could enhance long-term T1DM management by improving glycemic control and preventing organ damage, potentially inspiring the development of new food or pharmaceutical products with beneficial actions for T1DM. |
| format | Article |
| id | doaj-art-3ee7f9c388734f928569defa8bd6908a |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3ee7f9c388734f928569defa8bd6908a2025-01-12T05:24:45ZengElsevierJournal of Functional Foods1756-46462025-01-01124106638Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitusBárbara Cabral0Ony Araújo Galdino1Iago de Souza Gomes2Jovelina Samara Ferreira Alves3José Ivan Marques4Karla Simone Costa de Souza5Rodrigo Moreira da Silva6Bento João Abreu7Norberto Peporine Lopes8Silvana Maria Zucolotto9Adriana Augusto de Rezende10Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilDepartment of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilGraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilGraduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilGraduate Program in Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, BrazilGraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilDepartment of Biomolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, BrazilDepartment of Morphology, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilDepartment of Biomolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, BrazilGraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, BrazilGraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Corresponding author at: Federal University of Rio Grande do Norte (UFRN), Avenue Gen. Gustavo Cordeiro de Faria, sn, 59012-570, Natal, RN, Brazil.The study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from Passiflora edulis fo. flavicarpa, for Type 1 Diabetes mellitus (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the extracts (2000 mg/kg, orally) were safe. Liquid chromatography coupled to triple quadrupole mass spectrometry (LC-QqQ-MS/MS) identified five C-glycosylated flavonoids (vicenin-2, orientin, isoorientin, vitexin, isovitexin) in the extracts. Adjuvant treatment with extracts alongside insulin significantly improved glycemic control over 60 days compared to insulin alone (p < 0.05). Furthermore, extracts protected against renal fibrosis and maintenance of the levels of inflammatory markers, such as myeloperoxidase, in the hearts and kidneys of diabetic rats. These findings suggest passion fruit peel extracts could enhance long-term T1DM management by improving glycemic control and preventing organ damage, potentially inspiring the development of new food or pharmaceutical products with beneficial actions for T1DM.http://www.sciencedirect.com/science/article/pii/S1756464624006418Passiflora edulisFruit peelAntidiabetic agentsFlavonoidsSafety |
| spellingShingle | Bárbara Cabral Ony Araújo Galdino Iago de Souza Gomes Jovelina Samara Ferreira Alves José Ivan Marques Karla Simone Costa de Souza Rodrigo Moreira da Silva Bento João Abreu Norberto Peporine Lopes Silvana Maria Zucolotto Adriana Augusto de Rezende Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus Journal of Functional Foods Passiflora edulis Fruit peel Antidiabetic agents Flavonoids Safety |
| title | Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus |
| title_full | Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus |
| title_fullStr | Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus |
| title_full_unstemmed | Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus |
| title_short | Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus |
| title_sort | bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 diabetes mellitus |
| topic | Passiflora edulis Fruit peel Antidiabetic agents Flavonoids Safety |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006418 |
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