Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022
Objectives: The severity of the diarrhea disease is exacerbated by co-infections that involve Enterotoxigenic Escherichia coli (ETEC) and other enteric pathogens, which complicate the diagnosis and treatment. This study explores the prevalence, clinical manifestations, and risk factors of ETEC and i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224004405 |
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| author | Mohammad Ashraful Amin Marjahan Akhtar Zahid Hasan Khan Md Taufiqul Islam Md. Golam Firoj Yasmin Ara Begum Sadia Isfat Ara Rahman Mokibul Hassan Afrad Taufiqur Rahman Bhuiyan Fahima Chowdhury A.S.G. Faruque Edward T Ryan Firdausi Qadri Ashraful Islam Khan |
| author_facet | Mohammad Ashraful Amin Marjahan Akhtar Zahid Hasan Khan Md Taufiqul Islam Md. Golam Firoj Yasmin Ara Begum Sadia Isfat Ara Rahman Mokibul Hassan Afrad Taufiqur Rahman Bhuiyan Fahima Chowdhury A.S.G. Faruque Edward T Ryan Firdausi Qadri Ashraful Islam Khan |
| author_sort | Mohammad Ashraful Amin |
| collection | DOAJ |
| description | Objectives: The severity of the diarrhea disease is exacerbated by co-infections that involve Enterotoxigenic Escherichia coli (ETEC) and other enteric pathogens, which complicate the diagnosis and treatment. This study explores the prevalence, clinical manifestations, and risk factors of ETEC and its co-infections in Dhaka, Bangladesh. Methods: The study used data from the Diarrheal Disease Surveillance System at Dhaka Hospital, involving 16,276 patients from 2017 to 2022. We identified 1404 ETEC-positive patients from the 16,276 data points to investigate the association between ETEC infections, co-infections, and clinical outcomes. Results: ETEC was identified in 1404 (8.6%) of cases, representing the most common infection among adults (56.6%). ETEC co-infection occurred combined with V. cholerae (23%), Aeromonas (14.6%), rotavirus (11.8%), Campylobacter (6.5%), and Shigella spp. (1.7%), respectively. Adults were more likely to develop co-infections with ETEC and V. cholerae, while children under five were more likely to develop ETEC co-infections with rotavirus. Co-infections with V. cholerae, rotavirus, and Salmonella spp. increased the likelihood of fever, while ETEC co-infections with V. cholerae increased risks of vomiting, dehydration, and intravenous fluids. Conclusions: ETEC and co-infections exacerbate illness severity and overburden healthcare systems. Policymakers should prioritize resilient healthcare strategies for ETEC and co-infections. |
| format | Article |
| id | doaj-art-3ede24a2d8084fb195773cf5f27bd7b8 |
| institution | Kabale University |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-3ede24a2d8084fb195773cf5f27bd7b82025-01-06T04:08:33ZengElsevierInternational Journal of Infectious Diseases1201-97122025-02-01151107365Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022Mohammad Ashraful Amin0Marjahan Akhtar1Zahid Hasan Khan2Md Taufiqul Islam3Md. Golam Firoj4Yasmin Ara Begum5Sadia Isfat Ara Rahman6Mokibul Hassan Afrad7Taufiqur Rahman Bhuiyan8Fahima Chowdhury9A.S.G. Faruque10Edward T Ryan11Firdausi Qadri12Ashraful Islam Khan13Infectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh; Corresponding author: Ashraful Islam Khan, Mucosal Immunology and Vaccinology Unit, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.Objectives: The severity of the diarrhea disease is exacerbated by co-infections that involve Enterotoxigenic Escherichia coli (ETEC) and other enteric pathogens, which complicate the diagnosis and treatment. This study explores the prevalence, clinical manifestations, and risk factors of ETEC and its co-infections in Dhaka, Bangladesh. Methods: The study used data from the Diarrheal Disease Surveillance System at Dhaka Hospital, involving 16,276 patients from 2017 to 2022. We identified 1404 ETEC-positive patients from the 16,276 data points to investigate the association between ETEC infections, co-infections, and clinical outcomes. Results: ETEC was identified in 1404 (8.6%) of cases, representing the most common infection among adults (56.6%). ETEC co-infection occurred combined with V. cholerae (23%), Aeromonas (14.6%), rotavirus (11.8%), Campylobacter (6.5%), and Shigella spp. (1.7%), respectively. Adults were more likely to develop co-infections with ETEC and V. cholerae, while children under five were more likely to develop ETEC co-infections with rotavirus. Co-infections with V. cholerae, rotavirus, and Salmonella spp. increased the likelihood of fever, while ETEC co-infections with V. cholerae increased risks of vomiting, dehydration, and intravenous fluids. Conclusions: ETEC and co-infections exacerbate illness severity and overburden healthcare systems. Policymakers should prioritize resilient healthcare strategies for ETEC and co-infections.http://www.sciencedirect.com/science/article/pii/S1201971224004405Co-infectionsclinical impactdiarrheal diseasesenteric pathogensenterotoxigenic e. coli (ETEC) |
| spellingShingle | Mohammad Ashraful Amin Marjahan Akhtar Zahid Hasan Khan Md Taufiqul Islam Md. Golam Firoj Yasmin Ara Begum Sadia Isfat Ara Rahman Mokibul Hassan Afrad Taufiqur Rahman Bhuiyan Fahima Chowdhury A.S.G. Faruque Edward T Ryan Firdausi Qadri Ashraful Islam Khan Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 International Journal of Infectious Diseases Co-infections clinical impact diarrheal diseases enteric pathogens enterotoxigenic e. coli (ETEC) |
| title | Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 |
| title_full | Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 |
| title_fullStr | Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 |
| title_full_unstemmed | Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 |
| title_short | Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022 |
| title_sort | coinfection and clinical impact of enterotoxigenic escherichia coli harboring diverse toxin variants and colonization factors 2017 2022 |
| topic | Co-infections clinical impact diarrheal diseases enteric pathogens enterotoxigenic e. coli (ETEC) |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224004405 |
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