Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders

Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders

IntroductionChronic neuroinflammation is a persistent feature of individuals with Parkinson’s disease (PD). Dopaminergic neurodegeneration is partially associated with neuroinflammation. Neuron-to-microglia communication via fractalkine (CX3CL1) and its receptor plays a significant role in neuroinfl...

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Bibliographic Details
Main Authors: Yaping Chu, Ashley S. Harms, Ashley Boehringer, Jeffrey H. Kordower
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuron–microglia communication
neuroinflammation
microglia
CD4+ T lymphocyte
neurodegenerative disease
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1557645/full
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