Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma
2-deoxy-2-[18F]-fluoro-D-glucose (2-[18F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, predicting prognosis, and planning RT. Beside visual analysis, sev...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1515040/full |
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| author | Domenico Albano Domenico Albano Marco Ravanelli Rexhep Durmo Annibale Versari Angelina Filice Alessio Rizzo Manuela Racca Daniele Antonio Pizzuto Francesco Bertagna Francesco Bertagna Salvatore Annunziata |
| author_facet | Domenico Albano Domenico Albano Marco Ravanelli Rexhep Durmo Annibale Versari Angelina Filice Alessio Rizzo Manuela Racca Daniele Antonio Pizzuto Francesco Bertagna Francesco Bertagna Salvatore Annunziata |
| author_sort | Domenico Albano |
| collection | DOAJ |
| description | 2-deoxy-2-[18F]-fluoro-D-glucose (2-[18F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, predicting prognosis, and planning RT. Beside visual analysis, several semiquantitative parameters were introduced to study lymphoma with promising results. These parameters can represent different disease characteristics, like body composition (such as sarcopenic index), dissemination of disease (Dmax), tumor burden (including metabolic tumor volume) and texture features. All these parameters showed promising results, especially in terms of prognosis (progression free survival and overall survival), but lack of standardization and shared methodology remains a big issue. Advances in PET-based biomarkers are on the horizon, yet their integration into clinical decision-making is currently hindered by methodological limitations that require resolution through confirmatory prospective validation in specific patient groups. This review highlights studies demonstrating the prognostic and predictive value of these semiquantitative parameters in lymphoma, while also discussing their potential applicability in clinical practice. |
| format | Article |
| id | doaj-art-3ec32e6df5d747d5b7d31dda5b6c18f6 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-3ec32e6df5d747d5b7d31dda5b6c18f62024-12-18T06:43:43ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.15150401515040Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphomaDomenico Albano0Domenico Albano1Marco Ravanelli2Rexhep Durmo3Annibale Versari4Angelina Filice5Alessio Rizzo6Manuela Racca7Daniele Antonio Pizzuto8Francesco Bertagna9Francesco Bertagna10Salvatore Annunziata11Nuclear Medicine Unit, ASST Spedali Civili of Brescia, Brescia, ItalyDepartment of Nuclear Medicine, University of Brescia, Brescia, ItalyRadiology Unit, University of Brescia, Brescia, ItalyNuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, ItalyNuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, ItalyNuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, ItalyDivision of Nuclear Medicine, Candiolo Cancer Institute, FPO-IRCCS, Turin, ItalyDivision of Nuclear Medicine, Candiolo Cancer Institute, FPO-IRCCS, Turin, ItalyDipartimento di Radiodiagnostica e Radioterapia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyNuclear Medicine Unit, ASST Spedali Civili of Brescia, Brescia, ItalyDepartment of Nuclear Medicine, University of Brescia, Brescia, ItalyDipartimento di Radiodiagnostica e Radioterapia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy2-deoxy-2-[18F]-fluoro-D-glucose (2-[18F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, predicting prognosis, and planning RT. Beside visual analysis, several semiquantitative parameters were introduced to study lymphoma with promising results. These parameters can represent different disease characteristics, like body composition (such as sarcopenic index), dissemination of disease (Dmax), tumor burden (including metabolic tumor volume) and texture features. All these parameters showed promising results, especially in terms of prognosis (progression free survival and overall survival), but lack of standardization and shared methodology remains a big issue. Advances in PET-based biomarkers are on the horizon, yet their integration into clinical decision-making is currently hindered by methodological limitations that require resolution through confirmatory prospective validation in specific patient groups. This review highlights studies demonstrating the prognostic and predictive value of these semiquantitative parameters in lymphoma, while also discussing their potential applicability in clinical practice.https://www.frontiersin.org/articles/10.3389/fmed.2024.1515040/fullPET/CTlymphomaFDGsarcopeniaMTVTLG |
| spellingShingle | Domenico Albano Domenico Albano Marco Ravanelli Rexhep Durmo Annibale Versari Angelina Filice Alessio Rizzo Manuela Racca Daniele Antonio Pizzuto Francesco Bertagna Francesco Bertagna Salvatore Annunziata Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma Frontiers in Medicine PET/CT lymphoma FDG sarcopenia MTV TLG |
| title | Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma |
| title_full | Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma |
| title_fullStr | Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma |
| title_full_unstemmed | Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma |
| title_short | Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma |
| title_sort | semiquantitative 2 18f fdg pet ct based parameters role in lymphoma |
| topic | PET/CT lymphoma FDG sarcopenia MTV TLG |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1515040/full |
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