Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression
Esophageal carcinoma (EC) is one of the most common tumors in China and seriously affects patient survival and quality of life. In recent years, increasing studies have shown that the tumor microenvironment is crucial in promoting tumor progression and metastasis. Tumor-associated macrophages (TAM)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1450603/full |
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| author | Yuchao Tang Tingting Shi Shu Lin Shu Lin Taiyong Fang |
| author_facet | Yuchao Tang Tingting Shi Shu Lin Shu Lin Taiyong Fang |
| author_sort | Yuchao Tang |
| collection | DOAJ |
| description | Esophageal carcinoma (EC) is one of the most common tumors in China and seriously affects patient survival and quality of life. In recent years, increasing studies have shown that the tumor microenvironment is crucial in promoting tumor progression and metastasis. Tumor-associated macrophages (TAM) are key components of the tumor immune microenvironment and promote both tumor growth and antitumor immunity. Much evidence suggests that TAMs are closely associated with esophageal tumors. However, understanding of the clinical value and mechanism of action of TAM in esophageal cancer remains limited. Therefore, we reviewed the status of research on the role and mechanism of action of TAM in EC progression and summarized its potential clinical application value to provide a theoretical basis for the clinical treatment of EC. |
| format | Article |
| id | doaj-art-3eba0a072b5c42f7b07a8d4e3837b68f |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-3eba0a072b5c42f7b07a8d4e3837b68f2024-11-29T05:10:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14506031450603Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progressionYuchao Tang0Tingting Shi1Shu Lin2Shu Lin3Taiyong Fang4Department of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaCentre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaGroup of Neuroendocrinology, Garvan Institute of Medical Research, Sydney, AustraliaDepartment of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaEsophageal carcinoma (EC) is one of the most common tumors in China and seriously affects patient survival and quality of life. In recent years, increasing studies have shown that the tumor microenvironment is crucial in promoting tumor progression and metastasis. Tumor-associated macrophages (TAM) are key components of the tumor immune microenvironment and promote both tumor growth and antitumor immunity. Much evidence suggests that TAMs are closely associated with esophageal tumors. However, understanding of the clinical value and mechanism of action of TAM in esophageal cancer remains limited. Therefore, we reviewed the status of research on the role and mechanism of action of TAM in EC progression and summarized its potential clinical application value to provide a theoretical basis for the clinical treatment of EC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1450603/fulltumor-associated macrophagesesophageal carcinomatumor microenvironmentmechanismclinical treatment |
| spellingShingle | Yuchao Tang Tingting Shi Shu Lin Shu Lin Taiyong Fang Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression Frontiers in Oncology tumor-associated macrophages esophageal carcinoma tumor microenvironment mechanism clinical treatment |
| title | Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression |
| title_full | Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression |
| title_fullStr | Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression |
| title_full_unstemmed | Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression |
| title_short | Current status of research on the mechanisms of tumor-associated macrophages in esophageal cancer progression |
| title_sort | current status of research on the mechanisms of tumor associated macrophages in esophageal cancer progression |
| topic | tumor-associated macrophages esophageal carcinoma tumor microenvironment mechanism clinical treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1450603/full |
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