Clinical significance of high grade and low grade prostate intraepithelial neoplasia
Such premalignant conditions of prostate cancer (PC) as prostate intraepithelial neoplasia (PIN) are classified between benign and malignant ones. Contemporary evidence wheather PIN develops malignancy is limited and (LGPIN) data present varied results. Morphological and clinical differencies betwee...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dnipro State Medical University
2021-06-01
|
| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | http://journals.uran.ua/index.php/2307-0404/article/view/234640 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846147020706807808 |
|---|---|
| author | M.P. Melnychuk |
| author_facet | M.P. Melnychuk |
| author_sort | M.P. Melnychuk |
| collection | DOAJ |
| description | Such premalignant conditions of prostate cancer (PC) as prostate intraepithelial neoplasia (PIN) are classified between benign and malignant ones. Contemporary evidence wheather PIN develops malignancy is limited and (LGPIN) data present varied results. Morphological and clinical differencies between high (HGPIN) and low grade PIN specimens in the prostate remain unclear. Aim of the work – to determine clinical significance and progression ability of high grade and low grade prostate intraepithelial neoplasia. The results of examination of 276 patients with PIN (152 patients with high grade PIN and 134 patients with low grade PIN) were assessed comparatively. During a 3 year follow-up repeated prostate biopsies were performed with 6 months interval to detect PC. Initial and repeated multifocal transrectal prostate biopsies from 12 samples were performed under transrectal ultrasonic guidance. There were statistically significant differences in PC detection rates between HGPIN and LGPIN. Patients with HGPIN had malignization rate of 42.1% during a 3-year follow-up that was by 33.9% higher than in LGPIN patients. The spread of HGPIN lesions within prostate gland is a malignization risk factor. The mean malignization term of HGPIN is 18 months and of LGPIN – 30 months. Low and high grade PIN are gradual stages of cancerogenesis. PIN grade determines its clinical significance, while LGPIN has low malignization potential, HGPIN possesses morphological and clinical prostate characteristics similar to adenocarcinima. |
| format | Article |
| id | doaj-art-3ea2f2dea84b4528b5e13bc956d4e373 |
| institution | Kabale University |
| issn | 2307-0404 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-3ea2f2dea84b4528b5e13bc956d4e3732024-12-02T00:03:11ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042021-06-0126213414010.26641/2307-0404.2021.2.234640272304Clinical significance of high grade and low grade prostate intraepithelial neoplasiaM.P. Melnychuk0https://orcid.org/0000-0003-1194-3496State institution of science “Research and practical center of preventive and clinical medicine”, State administrative department, Verkhnia st., 5, Kyiv, 01014, UkraineSuch premalignant conditions of prostate cancer (PC) as prostate intraepithelial neoplasia (PIN) are classified between benign and malignant ones. Contemporary evidence wheather PIN develops malignancy is limited and (LGPIN) data present varied results. Morphological and clinical differencies between high (HGPIN) and low grade PIN specimens in the prostate remain unclear. Aim of the work – to determine clinical significance and progression ability of high grade and low grade prostate intraepithelial neoplasia. The results of examination of 276 patients with PIN (152 patients with high grade PIN and 134 patients with low grade PIN) were assessed comparatively. During a 3 year follow-up repeated prostate biopsies were performed with 6 months interval to detect PC. Initial and repeated multifocal transrectal prostate biopsies from 12 samples were performed under transrectal ultrasonic guidance. There were statistically significant differences in PC detection rates between HGPIN and LGPIN. Patients with HGPIN had malignization rate of 42.1% during a 3-year follow-up that was by 33.9% higher than in LGPIN patients. The spread of HGPIN lesions within prostate gland is a malignization risk factor. The mean malignization term of HGPIN is 18 months and of LGPIN – 30 months. Low and high grade PIN are gradual stages of cancerogenesis. PIN grade determines its clinical significance, while LGPIN has low malignization potential, HGPIN possesses morphological and clinical prostate characteristics similar to adenocarcinima.http://journals.uran.ua/index.php/2307-0404/article/view/234640high and low grade prostate intraepithelial neoplasiaprostate cancermalignant transformation |
| spellingShingle | M.P. Melnychuk Clinical significance of high grade and low grade prostate intraepithelial neoplasia Medičnì Perspektivi high and low grade prostate intraepithelial neoplasia prostate cancer malignant transformation |
| title | Clinical significance of high grade and low grade prostate intraepithelial neoplasia |
| title_full | Clinical significance of high grade and low grade prostate intraepithelial neoplasia |
| title_fullStr | Clinical significance of high grade and low grade prostate intraepithelial neoplasia |
| title_full_unstemmed | Clinical significance of high grade and low grade prostate intraepithelial neoplasia |
| title_short | Clinical significance of high grade and low grade prostate intraepithelial neoplasia |
| title_sort | clinical significance of high grade and low grade prostate intraepithelial neoplasia |
| topic | high and low grade prostate intraepithelial neoplasia prostate cancer malignant transformation |
| url | http://journals.uran.ua/index.php/2307-0404/article/view/234640 |
| work_keys_str_mv | AT mpmelnychuk clinicalsignificanceofhighgradeandlowgradeprostateintraepithelialneoplasia |