Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon

Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon

ABSTRACT Nuclear cyclic GMP-AMP synthetase (cGAS) binds to nucleosome with high affinity to prevent its activation by self-DNA. Upon stimulation with double-stranded DNA, cGAS is activated and translocates from the nucleus to the cytoplasm, guided by its N-terminal domain. However, it remains unclea...

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Bibliographic Details
Main Authors: Lei Wu, Ya Yan, Ye Yuan, Zhenchao Zhao, Weiyu Qu, Xiangyu Huang, Haiwei Wang, Pingwei Li, Xin Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
nuclear cGAS
Seneca Valley virus
3C protease
nucleosomal DNA
Online Access:https://journals.asm.org/doi/10.1128/mbio.03395-24
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