COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine
Abstract Mitochondria, as the cellular end-users of oxygen and responsible for approximately 98% of total body oxygen consumption, play a significant role in the development of organ dysfunction during shock. Therefore, integrating information on mitochondrial oxygen homeostasis with macroscopic obs...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-11-01
|
| Series: | Anesthesiology and Perioperative Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44254-024-00079-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846165613523763200 |
|---|---|
| author | Yan Yang Wei Zhang Zhengliang Ma Xiaoping Gu |
| author_facet | Yan Yang Wei Zhang Zhengliang Ma Xiaoping Gu |
| author_sort | Yan Yang |
| collection | DOAJ |
| description | Abstract Mitochondria, as the cellular end-users of oxygen and responsible for approximately 98% of total body oxygen consumption, play a significant role in the development of organ dysfunction during shock. Therefore, integrating information on mitochondrial oxygen homeostasis with macroscopic observations of macrocirculation and microcirculation is crucial for monitoring critically ill patients or those undergoing high-risk surgery. However, current clinical practice still lack reliable surrogate parameters for assessing mitochondrial function. The Cellular Oxygen METabolism (COMET) monitor, utilizing the protoporphyrin IX triplet state lifetime technique (PpIX-TSLT), represents the first clinical device capable of non-invasive, in vivo measurement of mitochondrial oxygen pressure and oxidative phosphorylation. Recent research suggests that implementing this real-time bedside monitoring will provide additional insights into microcirculatory dynamics and enhance patient management. This review will comprehensively detail the rationale, methodologies, evolution, and clinical applications of the technique, aiming at improving the understanding of mitochondrial pathology in daily clinical practice and facilitating the development of targeted therapeutic strategies. Graphical Abstract |
| format | Article |
| id | doaj-art-3e9a80007fae4ff9aef509c66f7b0fb6 |
| institution | Kabale University |
| issn | 2731-8389 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Anesthesiology and Perioperative Science |
| spelling | doaj-art-3e9a80007fae4ff9aef509c66f7b0fb62024-11-17T12:07:36ZengSpringerAnesthesiology and Perioperative Science2731-83892024-11-012411110.1007/s44254-024-00079-xCOMET: monitoring mitochondrial shock in anesthesiology and intensive care medicineYan Yang0Wei Zhang1Zhengliang Ma2Xiaoping Gu3Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityAbstract Mitochondria, as the cellular end-users of oxygen and responsible for approximately 98% of total body oxygen consumption, play a significant role in the development of organ dysfunction during shock. Therefore, integrating information on mitochondrial oxygen homeostasis with macroscopic observations of macrocirculation and microcirculation is crucial for monitoring critically ill patients or those undergoing high-risk surgery. However, current clinical practice still lack reliable surrogate parameters for assessing mitochondrial function. The Cellular Oxygen METabolism (COMET) monitor, utilizing the protoporphyrin IX triplet state lifetime technique (PpIX-TSLT), represents the first clinical device capable of non-invasive, in vivo measurement of mitochondrial oxygen pressure and oxidative phosphorylation. Recent research suggests that implementing this real-time bedside monitoring will provide additional insights into microcirculatory dynamics and enhance patient management. This review will comprehensively detail the rationale, methodologies, evolution, and clinical applications of the technique, aiming at improving the understanding of mitochondrial pathology in daily clinical practice and facilitating the development of targeted therapeutic strategies. Graphical Abstracthttps://doi.org/10.1007/s44254-024-00079-xCOMETMitochondrial oxygen metabolismNon-invasive monitoring at the bedsidePpIX-TSLT |
| spellingShingle | Yan Yang Wei Zhang Zhengliang Ma Xiaoping Gu COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine Anesthesiology and Perioperative Science COMET Mitochondrial oxygen metabolism Non-invasive monitoring at the bedside PpIX-TSLT |
| title | COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine |
| title_full | COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine |
| title_fullStr | COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine |
| title_full_unstemmed | COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine |
| title_short | COMET: monitoring mitochondrial shock in anesthesiology and intensive care medicine |
| title_sort | comet monitoring mitochondrial shock in anesthesiology and intensive care medicine |
| topic | COMET Mitochondrial oxygen metabolism Non-invasive monitoring at the bedside PpIX-TSLT |
| url | https://doi.org/10.1007/s44254-024-00079-x |
| work_keys_str_mv | AT yanyang cometmonitoringmitochondrialshockinanesthesiologyandintensivecaremedicine AT weizhang cometmonitoringmitochondrialshockinanesthesiologyandintensivecaremedicine AT zhengliangma cometmonitoringmitochondrialshockinanesthesiologyandintensivecaremedicine AT xiaopinggu cometmonitoringmitochondrialshockinanesthesiologyandintensivecaremedicine |