Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study
ObjectiveDiabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis level in DFU and traumatic wounds (TW) was monitored and the difference between them was analyzed. At the...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1412373/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841540188879192064 |
|---|---|
| author | Qian Jiang Long Tang Shuao Xiao |
| author_facet | Qian Jiang Long Tang Shuao Xiao |
| author_sort | Qian Jiang |
| collection | DOAJ |
| description | ObjectiveDiabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis level in DFU and traumatic wounds (TW) was monitored and the difference between them was analyzed. At the same time, this study further analyzed the correlation of ferroptosis levels with DM severity and DFU’s healing.MethodsA prospective cohort study was from January, 2021 to December, 2023 in the Second People’s Hospital of Gansu province, which included 59 patients with DFU and 42 patients with TW. We then used the kit to detect the indicators related to ferroptosis, including 4-Hydroxynonenal (4-HNE), Malondialdehyde (MDA) and reactive oxygen species (ROS), in the wound exudate of the two groups of patients.ResultsThe DFU group had higher ferroptosis level than the TW group (4-HNE: P = 0.003, MDA: P<0.001, ROS: P<0.001). The severity of diabetes was significantly associated with ferroptosis level in DFU patients(r = 0.936, P <0.001). The results of multiple regression analysis showed that 4-HNE (β = -0.182, P = 0.008), MDA (β = -0.478, P <0.001) and ROS (β = -0.394, P<0.001) significantly negatively predicted the healing rate of DFU.ConclusionAs a new monitoring and therapeutic target, ferroptosis level plays an important role in predicting the healing rate of DFU and assisting clinical treatment decision-making. |
| format | Article |
| id | doaj-art-3e989b93295547cc8ee9c14c41cef0e9 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-3e989b93295547cc8ee9c14c41cef0e92025-01-14T05:10:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14123731412373Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical studyQian Jiang0Long Tang1Shuao Xiao2Department of Geriatrics, Second People’s Hospital of Gansu Province, Lanzhou, ChinaDepartment of Burns and Plastic Surgery, Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Plastic Surgery, the First Affiliated Hospital of Air Force Medical University, Xi’an, ChinaObjectiveDiabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis level in DFU and traumatic wounds (TW) was monitored and the difference between them was analyzed. At the same time, this study further analyzed the correlation of ferroptosis levels with DM severity and DFU’s healing.MethodsA prospective cohort study was from January, 2021 to December, 2023 in the Second People’s Hospital of Gansu province, which included 59 patients with DFU and 42 patients with TW. We then used the kit to detect the indicators related to ferroptosis, including 4-Hydroxynonenal (4-HNE), Malondialdehyde (MDA) and reactive oxygen species (ROS), in the wound exudate of the two groups of patients.ResultsThe DFU group had higher ferroptosis level than the TW group (4-HNE: P = 0.003, MDA: P<0.001, ROS: P<0.001). The severity of diabetes was significantly associated with ferroptosis level in DFU patients(r = 0.936, P <0.001). The results of multiple regression analysis showed that 4-HNE (β = -0.182, P = 0.008), MDA (β = -0.478, P <0.001) and ROS (β = -0.394, P<0.001) significantly negatively predicted the healing rate of DFU.ConclusionAs a new monitoring and therapeutic target, ferroptosis level plays an important role in predicting the healing rate of DFU and assisting clinical treatment decision-making.https://www.frontiersin.org/articles/10.3389/fendo.2024.1412373/fullferroptosisdiabetic foot ulcerwound healingwound monitoringchronic wound healing |
| spellingShingle | Qian Jiang Long Tang Shuao Xiao Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study Frontiers in Endocrinology ferroptosis diabetic foot ulcer wound healing wound monitoring chronic wound healing |
| title | Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study |
| title_full | Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study |
| title_fullStr | Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study |
| title_full_unstemmed | Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study |
| title_short | Relationship between ferroptosis and healing of diabetic foot ulcer: a prospective clinical study |
| title_sort | relationship between ferroptosis and healing of diabetic foot ulcer a prospective clinical study |
| topic | ferroptosis diabetic foot ulcer wound healing wound monitoring chronic wound healing |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1412373/full |
| work_keys_str_mv | AT qianjiang relationshipbetweenferroptosisandhealingofdiabeticfootulceraprospectiveclinicalstudy AT longtang relationshipbetweenferroptosisandhealingofdiabeticfootulceraprospectiveclinicalstudy AT shuaoxiao relationshipbetweenferroptosisandhealingofdiabeticfootulceraprospectiveclinicalstudy |