Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway

Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway

Postpartum depression (PPD) adversely affects the growth and development of the offspring, increasing the risk of various internalizing behaviorsduring adolescence. Studies have shown that corticosterone (CORT)-induced PPD affects neurogenesis in the offspring, which is closely related to the onset...

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Bibliographic Details
Main Authors: Hongxiao Xie, Yanning Jiang, Xiumeng Zhang, Xinran Min, Jiuseng Zeng, Li Chen, Nan Zeng, Rong Liu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neurobiology of Stress
Subjects:
Postpartum depression
Offspring
HPA axis
BDNF-mTOR
Synaptic protein
Neurogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289525000025
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