Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis
Abstract Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic review evaluated the efficacy, effectiveness, immunogenicity, and safety of the pneumococcal conjugate vaccine (PCV)15 compared to other pneumococcal vaccines or no vaccinat...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-024-01048-y |
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| author | Gernot Wagner Gerald Gartlehner Kylie Thaler Dominic Ledinger Johanna Feyertag Irma Klerings KM Saif-Ur-Rahman Declan Devane Kate Olsson Karam Adel Ali Sabine Vygen-Bonnet Heini Salo Dace Zavadska Marta Grgič Vitek Marje Oona Robert Cunney David Tuerlinckx Frederikke Kristensen Lomholt Isolde Sommer |
| author_facet | Gernot Wagner Gerald Gartlehner Kylie Thaler Dominic Ledinger Johanna Feyertag Irma Klerings KM Saif-Ur-Rahman Declan Devane Kate Olsson Karam Adel Ali Sabine Vygen-Bonnet Heini Salo Dace Zavadska Marta Grgič Vitek Marje Oona Robert Cunney David Tuerlinckx Frederikke Kristensen Lomholt Isolde Sommer |
| author_sort | Gernot Wagner |
| collection | DOAJ |
| description | Abstract Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic review evaluated the efficacy, effectiveness, immunogenicity, and safety of the pneumococcal conjugate vaccine (PCV)15 compared to other pneumococcal vaccines or no vaccination in children and adults. We identified 20 randomized controlled trials (RCTs). A meta-analysis of six RCTs in infants showed that PCV15 was non-inferior compared with PCV13 for 12 shared serotypes. Based on a meta-analysis of seven RCTs in adults, PCV15 was non-inferior to PCV13 for 13 shared serotypes. For the unique PCV15 serotypes, 22F and 33F, immune responses were higher in infants and adults vaccinated with PCV15 compared to those receiving PCV13. Regarding safety, meta-analyses indicated comparable risks of adverse events between PCV15 and PCV13 in infants. Adults receiving PCV15 had a slightly higher risk of adverse events, though serious events were similar between groups. |
| format | Article |
| id | doaj-art-3e4416e682ab4a21ac4eb2865725be35 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-3e4416e682ab4a21ac4eb2865725be352025-01-05T12:07:59ZengNature Portfolionpj Vaccines2059-01052024-12-019111110.1038/s41541-024-01048-yImmunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysisGernot Wagner0Gerald Gartlehner1Kylie Thaler2Dominic Ledinger3Johanna Feyertag4Irma Klerings5KM Saif-Ur-Rahman6Declan Devane7Kate Olsson8Karam Adel Ali9Sabine Vygen-Bonnet10Heini Salo11Dace Zavadska12Marta Grgič Vitek13Marje Oona14Robert Cunney15David Tuerlinckx16Frederikke Kristensen Lomholt17Isolde Sommer18Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Evidence Synthesis Ireland and Cochrane Ireland, University of GalwayEvidence Synthesis Ireland and Cochrane Ireland, University of GalwayEuropean Centre for Disease Prevention and ControlEuropean Centre for Disease Prevention and ControlImmunisation Unit, Robert Koch InstituteInfectious Disease Control and Vaccinations Unit, Department of Health Security, Finnish Institute for Health and Welfare (THL)Department of Paediatrics, Children Clinical University Hospital, Rīgas Stradiņa UniversitāteCommunicable Diseases Centre, National Institute of Public HealthInstitute of Family Medicine and Public Health, University of TartuClinical Microbiology, Children’s Health Ireland at Temple StreetPediatric Department, Centre Hospitalier Universitaire (CHU) Dinant Godinne UCL NamurDepartment of Infectious Disease Epidemiology and Prevention, Statens Serum InstitutDepartment for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems)Abstract Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic review evaluated the efficacy, effectiveness, immunogenicity, and safety of the pneumococcal conjugate vaccine (PCV)15 compared to other pneumococcal vaccines or no vaccination in children and adults. We identified 20 randomized controlled trials (RCTs). A meta-analysis of six RCTs in infants showed that PCV15 was non-inferior compared with PCV13 for 12 shared serotypes. Based on a meta-analysis of seven RCTs in adults, PCV15 was non-inferior to PCV13 for 13 shared serotypes. For the unique PCV15 serotypes, 22F and 33F, immune responses were higher in infants and adults vaccinated with PCV15 compared to those receiving PCV13. Regarding safety, meta-analyses indicated comparable risks of adverse events between PCV15 and PCV13 in infants. Adults receiving PCV15 had a slightly higher risk of adverse events, though serious events were similar between groups.https://doi.org/10.1038/s41541-024-01048-y |
| spellingShingle | Gernot Wagner Gerald Gartlehner Kylie Thaler Dominic Ledinger Johanna Feyertag Irma Klerings KM Saif-Ur-Rahman Declan Devane Kate Olsson Karam Adel Ali Sabine Vygen-Bonnet Heini Salo Dace Zavadska Marta Grgič Vitek Marje Oona Robert Cunney David Tuerlinckx Frederikke Kristensen Lomholt Isolde Sommer Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis npj Vaccines |
| title | Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis |
| title_full | Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis |
| title_fullStr | Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis |
| title_full_unstemmed | Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis |
| title_short | Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis |
| title_sort | immunogenicity and safety of the 15 valent pneumococcal conjugate vaccine a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41541-024-01048-y |
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