Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

Abstract The growth of a tumor is tightly linked to the distribution of its cells along a continuum of activation states. Here, we systematically decode the activation state architecture (ASA) in a glioblastoma (GBM) patient cohort through comparison to adult murine neural stem cells. Modelling of t...

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Main Authors: Leo Carl Foerster, Oguzhan Kaya, Valentin Wüst, Diana-Patricia Danciu, Vuslat Akcay, Milica Bekavac, Kevin Chris Ziegler, Nina Stinchcombe, Anna Tang, Susanne Kleber, Joceyln Tang, Jan Brunken, Irene Lois-Bermejo, Noelia Gesteira-Perez, Xiujian Ma, Ahmed Sadik, Phuong Uyen Le, Kevin Petrecca, Christiane A. Opitz, Haikun Liu, Christian Rainer Wirtz, Angela Goncalves, Anna Marciniak-Czochra, Simon Anders, Ana Martin-Villalba
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62528-w
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