Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Abstract Background The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. A critical step in propagating pathologic Tau in the brain is the transport from the extracellular environment and accumulation inside naïve neurons. Current research ind...

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Main Authors: Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Neurodegeneration
Subjects:
Neurodegeneration
Cell-to-cell spreading
Extracellular Tau
Uptake
HSPGs
LRP1
Online Access:https://doi.org/10.1186/s13024-024-00786-w
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