COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study
Objectives To describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita.Design Prospective cohort study.Setting Recruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to...
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BMJ Publishing Group
2020-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e042090.full |
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| author | Charles Wade David Fluck Pankaj Sharma Aarti Sharma Gie Ken-Dror Shyam Sharma Jessica Law Cristina Russo Elizabeth Joy Joshua John Jonathan Robin Sarah John Karim Mahana Paul Bentley |
| author_facet | Charles Wade David Fluck Pankaj Sharma Aarti Sharma Gie Ken-Dror Shyam Sharma Jessica Law Cristina Russo Elizabeth Joy Joshua John Jonathan Robin Sarah John Karim Mahana Paul Bentley |
| author_sort | Charles Wade |
| collection | DOAJ |
| description | Objectives To describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita.Design Prospective cohort study.Setting Recruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to a single Surrey centre between March and April 2020. Extensive demographic details were documented.Outcome measure COVID-19 status of alive/dead and intensive care unit (ICU) status of yes/no.Participants Patients with COVID-19 from Surrey centre UK (n=429).Results 429 adult inpatients (mean age 70±18 years; men 56.4%) were included in this study, of whom, 19.1% required admission to ICU and 31.9% died. Adverse outcomes were associated with age (OR with each decade of years: 1.78, 95% CI 1.53 to 2.11, p<0.001 for mortality); male gender (OR=1.08, 95% CI 0.72 to 1.63, p=0.72, present in 70.7%, of admissions to ICU versus 53% of other cases, p=0.004); cardiac disease (OR=3.43, 95% CI 2.10 to 5.63, p<0.001), diabetes mellitus (OR=2.37, 95% CI 1.09 to 5.17, p=0.028) and dementia (OR=5.06, 95% CI 2.79 to 9.44, p<0.001). There was no significant impact of ethnicity or body mass index on disease outcome.Conclusions Despite reports of worse outcomes in deprived regions, we show similar complication and mortality rates due to COVID-19 in an affluent and high life expectancy region. |
| format | Article |
| id | doaj-art-3e2cb42ca1a14fc2b4c9a1c0cdfe47d9 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-3e2cb42ca1a14fc2b4c9a1c0cdfe47d92024-11-27T03:50:13ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-042090COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort studyCharles Wade0David Fluck1Pankaj Sharma2Aarti Sharma3Gie Ken-Dror4Shyam Sharma5Jessica Law6Cristina Russo7Elizabeth Joy8Joshua John9Jonathan Robin10Sarah John11Karim Mahana12Paul Bentley13Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK12 Cardiology, Ashford and Saint Peter`s Hospitals NHS Trust, Chertsey, Surrey, UKRoyal Holloway University of London, Egham, UKSchool of Medicine, Imperial College London, London, UKInstitute of Cardiovascular Research, Royal Holloway University of London, Egham, UKCollege of Medicine, University of Edinburgh, Edinburgh, ScotlandDivision of Medicine, Ashford and Saint Peter`s Hospitals NHS Foundation Trust, Chertsey, Surrey, UK3 Ashford and Saint Peter`s Hospitals NHS Trust, Chertsey, Surrey, UKDivision of Medicine, Ashford and Saint Peter`s Hospitals NHS Foundation Trust, Chertsey, Surrey, UKSchool of Medicine, Kings College London, London, UKDivision of Medicine, Ashford and Saint Peter`s Hospitals NHS Foundation Trust, Chertsey, Surrey, UK4 School of Clinical Medicine, University of Cambridge, Cambridge, Cambridgeshire, UKDivision of Medicine, Ashford and Saint Peter`s Hospitals NHS Foundation Trust, Chertsey, Surrey, UKBrain Sciences, Imperial College London, London, UKObjectives To describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita.Design Prospective cohort study.Setting Recruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to a single Surrey centre between March and April 2020. Extensive demographic details were documented.Outcome measure COVID-19 status of alive/dead and intensive care unit (ICU) status of yes/no.Participants Patients with COVID-19 from Surrey centre UK (n=429).Results 429 adult inpatients (mean age 70±18 years; men 56.4%) were included in this study, of whom, 19.1% required admission to ICU and 31.9% died. Adverse outcomes were associated with age (OR with each decade of years: 1.78, 95% CI 1.53 to 2.11, p<0.001 for mortality); male gender (OR=1.08, 95% CI 0.72 to 1.63, p=0.72, present in 70.7%, of admissions to ICU versus 53% of other cases, p=0.004); cardiac disease (OR=3.43, 95% CI 2.10 to 5.63, p<0.001), diabetes mellitus (OR=2.37, 95% CI 1.09 to 5.17, p=0.028) and dementia (OR=5.06, 95% CI 2.79 to 9.44, p<0.001). There was no significant impact of ethnicity or body mass index on disease outcome.Conclusions Despite reports of worse outcomes in deprived regions, we show similar complication and mortality rates due to COVID-19 in an affluent and high life expectancy region.https://bmjopen.bmj.com/content/10/11/e042090.full |
| spellingShingle | Charles Wade David Fluck Pankaj Sharma Aarti Sharma Gie Ken-Dror Shyam Sharma Jessica Law Cristina Russo Elizabeth Joy Joshua John Jonathan Robin Sarah John Karim Mahana Paul Bentley COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study BMJ Open |
| title | COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study |
| title_full | COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study |
| title_fullStr | COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study |
| title_full_unstemmed | COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study |
| title_short | COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study |
| title_sort | covid 19 outcomes in uk centre within highest health and wealth band a prospective cohort study |
| url | https://bmjopen.bmj.com/content/10/11/e042090.full |
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