A Novel Bispecific Anti-IL17/VEGF Fusion Trap Exhibits Potent and Long-Lasting Inhibitory Effects on the Development of Age-Related Macular Degeneration

A Novel Bispecific Anti-IL17/VEGF Fusion Trap Exhibits Potent and Long-Lasting Inhibitory Effects on the Development of Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a severe eye disease in people aged 60 years and older. Although anti-VEGF therapies are effective in treating neovascular AMD (NvAMD) in the clinic, up to 60% of patients do not completely respond to the therapies. Recent studies have shown that blood-deriv...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lan Deng, Lihua Wang, Yun Meng, Jidai Zheng, Xia Dong, Ying Chen, Haomin Huang
Format:	Article
Language:	English
Published:	Wiley 2024-01-01
Series:	Biochemistry Research International
Online Access:	http://dx.doi.org/10.1155/bri/1405338
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency
by: Xiaojuan Ma, et al.
Published: (2024-11-01)

Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo
by: Lu Wang, et al.
Published: (2024-12-01)

Macular hole with retinal pigment epithelium tear after anti-VEGF therapy in an eye with neovascular age-related macular degeneration
by: Tomoko Ando, et al.
Published: (2024-12-01)

Outcomes of Anti-VEGF Therapy in Eyes with Diabetic Macular Edema, Vein Occlusion-Related Macular Edema, and Neovascular Age-Related Macular Degeneration: A Systematic Review
by: Aldokhail LS, et al.
Published: (2024-12-01)

Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy
by: Selwyn M. Prea, et al.
Published: (2015-01-01)

Intravitreal Dexamethasone in Patients with Wet Age-Related Macular Degeneration Resistant to Anti-VEGF: A Prospective Pilot Study
by: Ermete Giancipoli, et al.
Published: (2018-01-01)

Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes
by: Ana Catarina Pedrosa, et al.
Published: (2017-01-01)

Anti-VEGF agents for the treatment of diabetic macular edema
by: S.G. Sergushev, et al.
Published: (2019-11-01)

Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
by: Jianqing Li, et al.
Published: (2018-01-01)

High-Affinity Fully Human Anti-EpCAM Antibody with Biased IL-2 Exhibits Potent Antitumor Activity
by: Zhi Wang, et al.
Published: (2024-11-01)

Knowledge, attitudes, and practices of patients with age-related macular degeneration (AMD) towards Anti-VEGF treatment under one-stop intravitreal injection model
by: Liangzhang Tan, et al.
Published: (2024-11-01)

A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity
by: Da-yan Zhang, et al.
Published: (2025-01-01)

The Role of Dietary Supplementation in the Prevention of Macular Degeneration: An Analysis of the Efficacy of Vitamins and Antioxidants in Inhibiting the Progression of Macular Degeneration
by: Sebastian Mrugała, et al.
Published: (2024-12-01)

Efficacy and Safety of Antivascular Endothelial Growth Factor (Anti-VEGF) in Treating Neovascular Age-Related Macular Degeneration (AMD): A Systematic Review and Meta-analysis
by: Xiaobei Yin, et al.
Published: (2022-01-01)

Anti-VEGF treatment outcome prediction based on optical coherence tomography images in neovascular age-related macular degeneration using a deep neural network
by: Jeong Mo Han, et al.
Published: (2024-11-01)

Stem cells for age-related macular degeneration
by: L.K. Moshetova, et al.
Published: (2019-09-01)

Targeted Therapy on Age-Related Macular Degeneration
by: Vankodoth Sireesha, et al.
Published: (2024-12-01)

Mechanism of Inflammation in Age-Related Macular Degeneration
by: Francesco Parmeggiani, et al.
Published: (2012-01-01)

Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review
by: Laura N. Distefano, et al.
Published: (2017-01-01)

Novel fabrication of anti-VEGF drug ranibizumab loaded PLGA/PLA co-polymeric nanomicelles for long-acting intraocular delivery in the treatment of age-related macular degeneration therapy
by: Jin-feng Xu, et al.
Published: (2024-06-01)

Minimal domain peptides derived from enterocins exhibit potent antifungal activity
by: Dorrian G. Cohen, et al.
Published: (2024-12-01)

Age-Related Macular Degeneration: Insights into Inflammatory Genes
by: Raffaella Cascella, et al.
Published: (2014-01-01)

Future Therapies of Wet Age-Related Macular Degeneration
by: Makoto Ishikawa, et al.
Published: (2015-01-01)

Ocular Surface Temperature in Age-Related Macular Degeneration
by: Andrea Sodi, et al.
Published: (2014-01-01)

IFN-γ- and IL-17-producing CD8+ T (Tc17-1) cells in combination with poly-ICLC and peptide vaccine exhibit antiglioma activity
by: Takayuki Ohkuri, et al.
Published: (2021-06-01)

Combination of Navigated Macular Laser Photocoagulation and Anti-VEGF Therapy: Precise Treatment for Macular Edema under Dry Retinal Conditions
by: Ernest V. Boiko, et al.
Published: (2017-01-01)

Switch to Aflibercept in Diabetic Macular Edema Patients Unresponsive to Previous Anti-VEGF Therapy
by: Filipe Mira, et al.
Published: (2017-01-01)

Adjunct Intravitreous Triamcinolone Acetonide in the Treatment of Diabetic Macular Edema with Anti-VEGF Agents
by: Robert B. Garoon, et al.
Published: (2016-01-01)

Application of deep learning algorithm for judicious use of anti-VEGF in diabetic macular edema
by: Anwesa Mondal, et al.
Published: (2025-02-01)

Optical Coherence Tomography Angiography of Macular Perfusion Changes after Anti-VEGF Therapy for Diabetic Macular Edema: A Systematic Review
by: Ayman G. Elnahry, et al.
Published: (2021-01-01)

Saffron therapy for the ongoing treatment of age-related macular degeneration
by: Peter J McCluskey, et al.
Published: (2024-07-01)

Berries and Their Active Compounds in Prevention of Age-Related Macular Degeneration
by: Xiang Li, et al.
Published: (2024-12-01)

Role of inflammatory aging in the development of age-related macular degeneration
by: A.S. Khalatyan, et al.
Published: (2024-09-01)

Practical application of a nutraceutical in age-related macular degeneration
by: T.G. Kamenskikh, et al.
Published: (2018-07-01)

Non-medical treatment for late age-related macular degeneration
by: A.K. Drakon, et al.
Published: (2021-12-01)

The first experience with brolucizumab for neovascular age-related macular degeneration
by: A.N. Kulikov, et al.
Published: (2022-05-01)

Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration
by: Chi-Chao Chan, et al.
Published: (2008-01-01)

Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration
by: Sara Toulouie, et al.
Published: (2022-01-01)

Interpretable multimodal classification for age-related macular degeneration diagnosis.
by: Carla Vairetti, et al.
Published: (2024-01-01)

Systemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study
by: Xi Liu, et al.
Published: (2024-12-01)