Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF
BackgroundIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. The blood urea nitrogen-to-albumin ratio (BAR) is a comprehensive parameter associated with inflammation status; however, it is unknown whether the BAR can pr...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1497530/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558761120989184 |
|---|---|
| author | Shaobo Ge Yuer Li Rui Li Jin Liu Rui Zhang Hongyan Fu Jingjing Tang Jie Zhang Nali Zhang Ming Zhang Ming Zhang |
| author_facet | Shaobo Ge Yuer Li Rui Li Jin Liu Rui Zhang Hongyan Fu Jingjing Tang Jie Zhang Nali Zhang Ming Zhang Ming Zhang |
| author_sort | Shaobo Ge |
| collection | DOAJ |
| description | BackgroundIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. The blood urea nitrogen-to-albumin ratio (BAR) is a comprehensive parameter associated with inflammation status; however, it is unknown whether the BAR can predict the prognosis of IPF.MethodsThis retrospective study included 176 patients with IPF, and 1-year all-cause mortality of these patients was recorded. A receiver operating characteristic (ROC) curve was used to explore the diagnostic value of BAR for 1-year all-cause mortality in IPF patients, and the survival rate was further estimated using the Kaplan–Meier survival curve. Cox proportional hazards regression model and forest plot were used to assess the association between the BAR and 1-year all-cause mortality in IPF patients.ResultsThe BAR of IPF patients was significantly higher in the non-survivor group than in the survivor group [0.16 (0.13–0.23) vs. 0.12 (0.09–0.17) mmol/g, p = 0.002]. The area under the ROC curve for predicting 1-year all-cause mortality in IPF patients was 0.671, and the optimal cut-off value was 0.12 mmol/g. The Kaplan–Meier survival curve showed that the 1-year cumulative survival rate of IPF patients with a BAR ≥0.12 was significantly decreased compared with the patients with a BAR <0.12. The Cox regression model and forest plot showed that the BAR was an independent prognostic biomarker for 1-year all-cause mortality in IPF patients (HR = 2.778, 95% CI 1.020–7.563, p = 0.046).ConclusionThe BAR is a significant predictor of 1-year all-cause mortality of IPF patients, and high BAR values may indicate poor clinical outcomes. |
| format | Article |
| id | doaj-art-3e09c438974843eebc6ab2ef52444686 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-3e09c438974843eebc6ab2ef524446862025-01-06T05:13:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14975301497530Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPFShaobo Ge0Yuer Li1Rui Li2Jin Liu3Rui Zhang4Hongyan Fu5Jingjing Tang6Jie Zhang7Nali Zhang8Ming Zhang9Ming Zhang10Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, Luoyang Hospital, The Second Affiliated Hospital of Xi’an Jiaotong University, Luoyang, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Respiratory and Critical Care Medicine, Luoyang Hospital, The Second Affiliated Hospital of Xi’an Jiaotong University, Luoyang, ChinaBackgroundIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. The blood urea nitrogen-to-albumin ratio (BAR) is a comprehensive parameter associated with inflammation status; however, it is unknown whether the BAR can predict the prognosis of IPF.MethodsThis retrospective study included 176 patients with IPF, and 1-year all-cause mortality of these patients was recorded. A receiver operating characteristic (ROC) curve was used to explore the diagnostic value of BAR for 1-year all-cause mortality in IPF patients, and the survival rate was further estimated using the Kaplan–Meier survival curve. Cox proportional hazards regression model and forest plot were used to assess the association between the BAR and 1-year all-cause mortality in IPF patients.ResultsThe BAR of IPF patients was significantly higher in the non-survivor group than in the survivor group [0.16 (0.13–0.23) vs. 0.12 (0.09–0.17) mmol/g, p = 0.002]. The area under the ROC curve for predicting 1-year all-cause mortality in IPF patients was 0.671, and the optimal cut-off value was 0.12 mmol/g. The Kaplan–Meier survival curve showed that the 1-year cumulative survival rate of IPF patients with a BAR ≥0.12 was significantly decreased compared with the patients with a BAR <0.12. The Cox regression model and forest plot showed that the BAR was an independent prognostic biomarker for 1-year all-cause mortality in IPF patients (HR = 2.778, 95% CI 1.020–7.563, p = 0.046).ConclusionThe BAR is a significant predictor of 1-year all-cause mortality of IPF patients, and high BAR values may indicate poor clinical outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2024.1497530/fullidiopathic pulmonary fibrosisprognosisurea nitrogenalbuminbiomarker |
| spellingShingle | Shaobo Ge Yuer Li Rui Li Jin Liu Rui Zhang Hongyan Fu Jingjing Tang Jie Zhang Nali Zhang Ming Zhang Ming Zhang Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF Frontiers in Medicine idiopathic pulmonary fibrosis prognosis urea nitrogen albumin biomarker |
| title | Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF |
| title_full | Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF |
| title_fullStr | Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF |
| title_full_unstemmed | Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF |
| title_short | Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF |
| title_sort | blood urea nitrogen to albumin ratio as a new prognostic indicator of 1 year all cause mortality in patients with ipf |
| topic | idiopathic pulmonary fibrosis prognosis urea nitrogen albumin biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1497530/full |
| work_keys_str_mv | AT shaoboge bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT yuerli bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT ruili bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT jinliu bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT ruizhang bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT hongyanfu bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT jingjingtang bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT jiezhang bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT nalizhang bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT mingzhang bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf AT mingzhang bloodureanitrogentoalbuminratioasanewprognosticindicatorof1yearallcausemortalityinpatientswithipf |