High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon
<i>Introduction:</i> Cryptococcal meningitis is a major cause of death in HIV/AIDS patients due to the existence of <i>Cryptococcus neoformans</i> in the central nervous system. Our objective was to evaluate the prevalence of Cryptococcus antigenuria in a population of HIV-in...
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MDPI AG
2024-12-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/9/12/312 |
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| author | Roger Hadry Sibi Matotou Denise Patricia Mawili-Mboumba Charlène Manomba Bridy Chesly Moutombi Ditombi Coella Joyce Mihindou Dimitri Ardin Moussavou Mabicka Arsène Mounomby Solange Nzenze Afene Marielle Karine Bouyou Akotet |
| author_facet | Roger Hadry Sibi Matotou Denise Patricia Mawili-Mboumba Charlène Manomba Bridy Chesly Moutombi Ditombi Coella Joyce Mihindou Dimitri Ardin Moussavou Mabicka Arsène Mounomby Solange Nzenze Afene Marielle Karine Bouyou Akotet |
| author_sort | Roger Hadry Sibi Matotou |
| collection | DOAJ |
| description | <i>Introduction:</i> Cryptococcal meningitis is a major cause of death in HIV/AIDS patients due to the existence of <i>Cryptococcus neoformans</i> in the central nervous system. Our objective was to evaluate the prevalence of Cryptococcus antigenuria in a population of HIV-infected patients in Libreville, Gabon. <i>Patients and Methods</i>: This study was conducted from April to October 2021 at the Infectious Diseases ward of the Centre Hospitalier Universitaire de Libreville. Hospitalized patients with HIV were included. The detection of cryptococcal antigen (CrAg) in urine was performed using the Pastorex Crypto Plus Kit. <i>Results</i>: Out of the 255 PLHIV, 142 benefited from the CrAg detection. The prevalence of urine CrAg was 24.6% (n = 35). The majority of CrAg+ patients (82.8%; n = 29) were under 55 years old. Almost three-quarters of them (n = 25; 71.4%) had CD4 counts < 200, and 80.0% (n = 28) were at WHO clinical stages III and IV. All patients with neck stiffness at admission had a CrAg positive test. <i>Conclusion</i>: This study showed a non-negligible prevalence of Cryptococcal urinary antigen in HIV-infected patients with neurological symptoms. These data underline the importance of CrAg screening in routine care for better management of PLHIV. |
| format | Article |
| id | doaj-art-3dff9990ebe642e8ae2980568b6e52e1 |
| institution | Kabale University |
| issn | 2414-6366 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-3dff9990ebe642e8ae2980568b6e52e12024-12-27T14:57:12ZengMDPI AGTropical Medicine and Infectious Disease2414-63662024-12-0191231210.3390/tropicalmed9120312High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, GabonRoger Hadry Sibi Matotou0Denise Patricia Mawili-Mboumba1Charlène Manomba2Bridy Chesly Moutombi Ditombi3Coella Joyce Mihindou4Dimitri Ardin Moussavou Mabicka5Arsène Mounomby6Solange Nzenze Afene7Marielle Karine Bouyou Akotet8Department of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Internal Medicine, Division of Infectious Diseases, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, GabonDepartment of Parasitology, Mycology and Tropical Medicine, Université des Sciences de la Santé (USS), Libreville BP 4009, Gabon<i>Introduction:</i> Cryptococcal meningitis is a major cause of death in HIV/AIDS patients due to the existence of <i>Cryptococcus neoformans</i> in the central nervous system. Our objective was to evaluate the prevalence of Cryptococcus antigenuria in a population of HIV-infected patients in Libreville, Gabon. <i>Patients and Methods</i>: This study was conducted from April to October 2021 at the Infectious Diseases ward of the Centre Hospitalier Universitaire de Libreville. Hospitalized patients with HIV were included. The detection of cryptococcal antigen (CrAg) in urine was performed using the Pastorex Crypto Plus Kit. <i>Results</i>: Out of the 255 PLHIV, 142 benefited from the CrAg detection. The prevalence of urine CrAg was 24.6% (n = 35). The majority of CrAg+ patients (82.8%; n = 29) were under 55 years old. Almost three-quarters of them (n = 25; 71.4%) had CD4 counts < 200, and 80.0% (n = 28) were at WHO clinical stages III and IV. All patients with neck stiffness at admission had a CrAg positive test. <i>Conclusion</i>: This study showed a non-negligible prevalence of Cryptococcal urinary antigen in HIV-infected patients with neurological symptoms. These data underline the importance of CrAg screening in routine care for better management of PLHIV.https://www.mdpi.com/2414-6366/9/12/312PLHIV<i>Cryptococcus</i>antigenurineGabon |
| spellingShingle | Roger Hadry Sibi Matotou Denise Patricia Mawili-Mboumba Charlène Manomba Bridy Chesly Moutombi Ditombi Coella Joyce Mihindou Dimitri Ardin Moussavou Mabicka Arsène Mounomby Solange Nzenze Afene Marielle Karine Bouyou Akotet High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon Tropical Medicine and Infectious Disease PLHIV <i>Cryptococcus</i> antigen urine Gabon |
| title | High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon |
| title_full | High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon |
| title_fullStr | High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon |
| title_full_unstemmed | High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon |
| title_short | High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon |
| title_sort | high cryptococcal antigenuria prevalence in a population of plhiv with neurological symptoms hospitalized in the infectious diseases wards of the centre hospitalier universitaire de libreville gabon |
| topic | PLHIV <i>Cryptococcus</i> antigen urine Gabon |
| url | https://www.mdpi.com/2414-6366/9/12/312 |
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