Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition characterized by persistent nasal obstruction, discharge, facial pressure, and olfactory dysfunction. CRSwNP significantly impairs quality of life (QoL), with olfactory loss being a particularly distressing symp...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2024.1519069/full |
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| author | Francesca Anastasi Francesca Anastasi Frank Rikki Mauritz Canevari Frank Rikki Mauritz Canevari Stefania Gallo Giulia Gramellini Enrico Heffler Enrico Heffler Ignazio La Mantia Giulia Monti Martina Ragusa Alberto Macchi |
| author_facet | Francesca Anastasi Francesca Anastasi Frank Rikki Mauritz Canevari Frank Rikki Mauritz Canevari Stefania Gallo Giulia Gramellini Enrico Heffler Enrico Heffler Ignazio La Mantia Giulia Monti Martina Ragusa Alberto Macchi |
| author_sort | Francesca Anastasi |
| collection | DOAJ |
| description | BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition characterized by persistent nasal obstruction, discharge, facial pressure, and olfactory dysfunction. CRSwNP significantly impairs quality of life (QoL), with olfactory loss being a particularly distressing symptom that affects food enjoyment, personal safety, and social interactions.MethodsThis study investigated the experiences of Italian patients with CRSwNP. A cross-sectional quantitative and qualitative survey (Google Forms questionnaire), collecting data on diagnosis, symptomatology, QoL impact, and treatment experiences was developed and distributed.ResultsThere were 155 respondents, with over half diagnosed with CRSwNP for more than a decade. Nasal obstruction was the primary symptom leading to medical consultation. Corticosteroid therapy and surgery showed limited and variable effectiveness in olfactory restoration. Biologic therapy, particularly dupilumab, demonstrated promising results, with approximately half of the patients reporting complete smell restoration.ConclusionsCRSwNP significantly affected patients' QoL, with olfactory dysfunction being a common and impactful symptom. While current treatments provide symptom relief, they do not always result in sustained olfactory improvement. Biologic therapy emerged as a promising option for olfactory restoration, underscoring the importance of personalized treatment strategies. Further research is warranted to explore the mechanisms of olfactory recovery and to optimize treatment protocols for CRSwNP. |
| format | Article |
| id | doaj-art-3dfd328526e94d219e486cab341ab903 |
| institution | Kabale University |
| issn | 2673-6101 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj-art-3dfd328526e94d219e486cab341ab9032025-01-07T06:45:47ZengFrontiers Media S.A.Frontiers in Allergy2673-61012025-01-01510.3389/falgy.2024.15190691519069Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered surveyFrancesca Anastasi0Francesca Anastasi1Frank Rikki Mauritz Canevari2Frank Rikki Mauritz Canevari3Stefania Gallo4Giulia Gramellini5Enrico Heffler6Enrico Heffler7Ignazio La Mantia8Giulia Monti9Martina Ragusa10Alberto Macchi11Unit of Otorhinolaryngology, Medical and Surgical Rhinology, Ospedale San Giovanni Evangelista, Tivoli, ItalyFacoltà Dipartimentale di Medicina, UniCamillus—Saint Camillus International University of Health and Medical Sciences, Rome, ItalyUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino Genoa, Genoa, ItalyDepartment of Surgical Sciences Integrated Diagnostics (DISC), University of Genoa, Genoa, ItalyUnit of Otorhinolaryngology, Head and Neck Department, ASST Sette Laghi, Varese and UPLOAD (Upper and Lower Airways Diseases) Research Centre, University of Insubria, Varese, ItalyUnit of Otorhinolaryngology, ASST GOM Niguarda, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, ItalyUnit of Otorhinolaryngology, Department of Medical, Surgical, and Advanced Technologies “G.F. Ingrassia”, University of Catania, Catania, Italy0Unit of Otorhinolaryngology-Head and Neck Department, ASST Sette Laghi, University of Insubria, Varese, Italy1Department of Medical-Surgical Sciences and Advanced Technologies, E.N.T. Unit, P.O. “G. Rodolico”, University of Catania, Catania, Italy2Unit of Otorhinolaryngology-Head and Neck Department, ASST Sette Laghi, Varese and UPLOAD (Upper and Lower Airways Diseases) Research Centre, University of Insubria, Varese, ItalyBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition characterized by persistent nasal obstruction, discharge, facial pressure, and olfactory dysfunction. CRSwNP significantly impairs quality of life (QoL), with olfactory loss being a particularly distressing symptom that affects food enjoyment, personal safety, and social interactions.MethodsThis study investigated the experiences of Italian patients with CRSwNP. A cross-sectional quantitative and qualitative survey (Google Forms questionnaire), collecting data on diagnosis, symptomatology, QoL impact, and treatment experiences was developed and distributed.ResultsThere were 155 respondents, with over half diagnosed with CRSwNP for more than a decade. Nasal obstruction was the primary symptom leading to medical consultation. Corticosteroid therapy and surgery showed limited and variable effectiveness in olfactory restoration. Biologic therapy, particularly dupilumab, demonstrated promising results, with approximately half of the patients reporting complete smell restoration.ConclusionsCRSwNP significantly affected patients' QoL, with olfactory dysfunction being a common and impactful symptom. While current treatments provide symptom relief, they do not always result in sustained olfactory improvement. Biologic therapy emerged as a promising option for olfactory restoration, underscoring the importance of personalized treatment strategies. Further research is warranted to explore the mechanisms of olfactory recovery and to optimize treatment protocols for CRSwNP.https://www.frontiersin.org/articles/10.3389/falgy.2024.1519069/fullbiologic therapychronic rhinosinusitis with nasal polyps (CRSwNP)dupilumabolfactory restorationsmell |
| spellingShingle | Francesca Anastasi Francesca Anastasi Frank Rikki Mauritz Canevari Frank Rikki Mauritz Canevari Stefania Gallo Giulia Gramellini Enrico Heffler Enrico Heffler Ignazio La Mantia Giulia Monti Martina Ragusa Alberto Macchi Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey Frontiers in Allergy biologic therapy chronic rhinosinusitis with nasal polyps (CRSwNP) dupilumab olfactory restoration smell |
| title | Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey |
| title_full | Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey |
| title_fullStr | Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey |
| title_full_unstemmed | Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey |
| title_short | Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey |
| title_sort | olfactory impairment in italian patients with chronic rhinosinusitis with nasal polyps a patient centered survey |
| topic | biologic therapy chronic rhinosinusitis with nasal polyps (CRSwNP) dupilumab olfactory restoration smell |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2024.1519069/full |
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