Myosin VI drives arrestin-independent internalization and signaling of GPCRs

Myosin VI drives arrestin-independent internalization and signaling of GPCRs

Abstract G protein-coupled receptor (GPCR) endocytosis is canonically associated with β-arrestins. Here, we delineate a β-arrestin-independent endocytic pathway driven by the cytoskeletal motor, myosin VI. Myosin VI engages GIPC, an adaptor protein that binds a PDZ sequence motif present at the C-te...

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Main Authors: Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55053-9
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