Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease
The article presents the results of vaccination against diphtheria, tetanus and hepatitis B virus with the use of combined vaccine Bubo-M or a monovalent vaccine Hepatitis B in 120 patients with severe and medium chronic obstructive pulmonary disease (COPD) and 77 healthy people at the age 35 - 60 y...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2017-08-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/294 |
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| author | M. P. Kostinov N. A. Kulakova O. O. Magarshak V. N. Borisova V. B. Polishchuk A. M. Kostinova A. A. Ryzhov A. M. Kostinov |
| author_facet | M. P. Kostinov N. A. Kulakova O. O. Magarshak V. N. Borisova V. B. Polishchuk A. M. Kostinova A. A. Ryzhov A. M. Kostinov |
| author_sort | M. P. Kostinov |
| collection | DOAJ |
| description | The article presents the results of vaccination against diphtheria, tetanus and hepatitis B virus with the use of combined vaccine Bubo-M or a monovalent vaccine Hepatitis B in 120 patients with severe and medium chronic obstructive pulmonary disease (COPD) and 77 healthy people at the age 35 - 60 years. The lack of protective antibodies to diphtheria in patients with COPD was noted. The safety of immunization and the delayed production of post-vaccination antibodies to these infections were shown. The level of post-vaccination antibodies was the same as in healthy group after the administration of 3-rd dose both of the monovaccine and the combined one. During the year a clinical effect in reducing the number of exacerbations of the disease after a triple injection of the combined Bubo-M vaccine in patients with COPD was observed, comparable to that in patients with the combined use of the immunomodulator and hepatitis B vaccine. Moreover combined vaccination with immunomodulator led to normalization of level of the inflammatory mediators. Conclusion: Vaccination of patients with COPD with the use of the combined vaccine Bubo-M has both an advantages in clinical effect and the spectrum of anti-infection protection in comparison with the monovaccine against hepatitis |
| format | Article |
| id | doaj-art-3de8bf4f4b5a483da9da38679543c93c |
| institution | Kabale University |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2017-08-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-3de8bf4f4b5a483da9da38679543c93c2025-08-20T03:57:18ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942017-08-01164445110.31631/2073-3046-2017-16-4-44-51293Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary DiseaseM. P. Kostinov0N. A. Kulakova1O. O. Magarshak2V. N. Borisova3V. B. Polishchuk4A. M. Kostinova5A. A. Ryzhov6A. M. Kostinov7Federal State Research Institution «Scientific Research Institute of Vaccines and Sera named after I.I. Mechnikov»; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of RussiaFederal State Research Institution «Scientific Research Institute of Vaccines and Sera named after I.I. Mechnikov»Federal State Research Institution «Scientific Research Institute of Vaccines and Sera named after I.I. Mechnikov»Scientific and Production Company «Kombiotech»Federal State Research Institution «Scientific Research Institute of Vaccines and Sera named after I.I. Mechnikov»National Research Center «Institute of Immunology» Federal Medical-Biological Agency of RussiaFederal State Research Institution «Scientific Research Institute of Vaccines and Sera named after I.I. Mechnikov»Lomonosov Moscow State UniversityThe article presents the results of vaccination against diphtheria, tetanus and hepatitis B virus with the use of combined vaccine Bubo-M or a monovalent vaccine Hepatitis B in 120 patients with severe and medium chronic obstructive pulmonary disease (COPD) and 77 healthy people at the age 35 - 60 years. The lack of protective antibodies to diphtheria in patients with COPD was noted. The safety of immunization and the delayed production of post-vaccination antibodies to these infections were shown. The level of post-vaccination antibodies was the same as in healthy group after the administration of 3-rd dose both of the monovaccine and the combined one. During the year a clinical effect in reducing the number of exacerbations of the disease after a triple injection of the combined Bubo-M vaccine in patients with COPD was observed, comparable to that in patients with the combined use of the immunomodulator and hepatitis B vaccine. Moreover combined vaccination with immunomodulator led to normalization of level of the inflammatory mediators. Conclusion: Vaccination of patients with COPD with the use of the combined vaccine Bubo-M has both an advantages in clinical effect and the spectrum of anti-infection protection in comparison with the monovaccine against hepatitishttps://www.epidemvac.ru/jour/article/view/294хоблкомплексная вакцинапоствакцинальные антителадифтериястолбнякгепатит вcopdassociated vaccinepost-vaccination antibodiesdiphtheriatetanushepatitis b |
| spellingShingle | M. P. Kostinov N. A. Kulakova O. O. Magarshak V. N. Borisova V. B. Polishchuk A. M. Kostinova A. A. Ryzhov A. M. Kostinov Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease Эпидемиология и вакцинопрофилактика хобл комплексная вакцина поствакцинальные антитела дифтерия столбняк гепатит в copd associated vaccine post-vaccination antibodies diphtheria tetanus hepatitis b |
| title | Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease |
| title_full | Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease |
| title_fullStr | Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease |
| title_short | Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease |
| title_sort | immunogenicity and clinical efficacy combined vaccine against diphtheria tetanus and hepatitis b in patients with chronic obstructive pulmonary disease |
| topic | хобл комплексная вакцина поствакцинальные антитела дифтерия столбняк гепатит в copd associated vaccine post-vaccination antibodies diphtheria tetanus hepatitis b |
| url | https://www.epidemvac.ru/jour/article/view/294 |
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