Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder
Abstract Objective Major depressive disorder (MDD) is known to be characterized by disrupted brain functional network connectivity (FNC) patterns, while the dynamic change mode of different functional networks is unclear. This study aimed to characterize specific dynamic alterations pattern on intri...
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2024-12-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-024-06356-0 |
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| author | Min Wang Tao Chen Zhongyi He Lawrence Wing-Chi Chan Qinger Guo Shuyang Cai Jingfeng Duan Danbin Zhang Xunda Wang Yu Fang Hong Yang |
| author_facet | Min Wang Tao Chen Zhongyi He Lawrence Wing-Chi Chan Qinger Guo Shuyang Cai Jingfeng Duan Danbin Zhang Xunda Wang Yu Fang Hong Yang |
| author_sort | Min Wang |
| collection | DOAJ |
| description | Abstract Objective Major depressive disorder (MDD) is known to be characterized by disrupted brain functional network connectivity (FNC) patterns, while the dynamic change mode of different functional networks is unclear. This study aimed to characterize specific dynamic alterations pattern on intrinsic FNC in MDD by combining static FNC (sFNC) and dynamic FNC (dFNC). Methods A total of 48 first-episode drug-naïve MDD and 48 matched healthy controls (HCs) were included in this study. The sFNC and dFNC were analyzed using complete time-series and sliding window approach, respectively. Both sFNC and dFNC differences between groups were analyzed and associations between disease severity and aberrant FNC were explored. Results MDD patients exhibited lower sFNC within and between sensory and motor networks than HC. Four dFNC states were identified, including a globally-weakly-connected state, a cognitive-control-dominated state, a globally-positively-connected state, and an antagonistic state. The antagonistic state was marked by strong positive connections within the sensorimotor domain and their anti-correlations with the executive-motor control domain. Notably, MDD patients exhibited significantly longer dwell time in the globally-weakly-connected state, at the cost of significantly shorter dwell time in the antagonistic state. Further, only the mean dwell time of this antagonistic state was significantly anticorrelated to disease severity measures. Conclusions Our study highlights the altered dynamics of the antagonistic state as a fundamental aspect of disrupted FNC in early MDD. |
| format | Article |
| id | doaj-art-3dda3b71bcbd466a9f89c5ed68ccab12 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-3dda3b71bcbd466a9f89c5ed68ccab122024-12-22T12:40:18ZengBMCBMC Psychiatry1471-244X2024-12-0124111310.1186/s12888-024-06356-0Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorderMin Wang0Tao Chen1Zhongyi He2Lawrence Wing-Chi Chan3Qinger Guo4Shuyang Cai5Jingfeng Duan6Danbin Zhang7Xunda Wang8Yu Fang9Hong Yang10Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang UniversityDepartment of Radiology, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang UniversityDepartment of Health Technology and Informatics, Hong Kong Polytechnic UniversityDepartment of Radiology, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityDepartment of Radiology, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityDepartment of Psychiatry, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityDepartment of Radiology, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityDepartment of Psychiatry & Behavioral Sciences, Stanford University School of MedicineDepartment of Radiology, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityDepartment of Radiology, College of Medicine, The First Affiliated Hospital, Zhejiang UniversityAbstract Objective Major depressive disorder (MDD) is known to be characterized by disrupted brain functional network connectivity (FNC) patterns, while the dynamic change mode of different functional networks is unclear. This study aimed to characterize specific dynamic alterations pattern on intrinsic FNC in MDD by combining static FNC (sFNC) and dynamic FNC (dFNC). Methods A total of 48 first-episode drug-naïve MDD and 48 matched healthy controls (HCs) were included in this study. The sFNC and dFNC were analyzed using complete time-series and sliding window approach, respectively. Both sFNC and dFNC differences between groups were analyzed and associations between disease severity and aberrant FNC were explored. Results MDD patients exhibited lower sFNC within and between sensory and motor networks than HC. Four dFNC states were identified, including a globally-weakly-connected state, a cognitive-control-dominated state, a globally-positively-connected state, and an antagonistic state. The antagonistic state was marked by strong positive connections within the sensorimotor domain and their anti-correlations with the executive-motor control domain. Notably, MDD patients exhibited significantly longer dwell time in the globally-weakly-connected state, at the cost of significantly shorter dwell time in the antagonistic state. Further, only the mean dwell time of this antagonistic state was significantly anticorrelated to disease severity measures. Conclusions Our study highlights the altered dynamics of the antagonistic state as a fundamental aspect of disrupted FNC in early MDD.https://doi.org/10.1186/s12888-024-06356-0Major depressive disorderDynamic functional connectivityNetwork antagonismResting-state functional magnetic resonance imaging |
| spellingShingle | Min Wang Tao Chen Zhongyi He Lawrence Wing-Chi Chan Qinger Guo Shuyang Cai Jingfeng Duan Danbin Zhang Xunda Wang Yu Fang Hong Yang Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder BMC Psychiatry Major depressive disorder Dynamic functional connectivity Network antagonism Resting-state functional magnetic resonance imaging |
| title | Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder |
| title_full | Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder |
| title_fullStr | Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder |
| title_full_unstemmed | Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder |
| title_short | Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder |
| title_sort | altered dynamic functional connectivity in antagonistic state in first episode drug naive patients with major depressive disorder |
| topic | Major depressive disorder Dynamic functional connectivity Network antagonism Resting-state functional magnetic resonance imaging |
| url | https://doi.org/10.1186/s12888-024-06356-0 |
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