Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies
Anti-GAD antibody syndrome is a result of the production of antibodies against glutamic acid decarboxylase (GAD), the main enzyme responsible for the production of gamma-aminobutyric acid (GABA). Several neurological manifestations including cerebellar ataxia and stiff person syndrome have been repo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2020/8454532 |
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| author | Sinali O. Seneviratne Katherine A. Buzzard Belinda Cruse Mastura Monif |
| author_facet | Sinali O. Seneviratne Katherine A. Buzzard Belinda Cruse Mastura Monif |
| author_sort | Sinali O. Seneviratne |
| collection | DOAJ |
| description | Anti-GAD antibody syndrome is a result of the production of antibodies against glutamic acid decarboxylase (GAD), the main enzyme responsible for the production of gamma-aminobutyric acid (GABA). Several neurological manifestations including cerebellar ataxia and stiff person syndrome have been reported in association with anti-GAD antibodies. In this paper, we present a case of a young woman with anti-GAD antibodies who initially presented with cerebellar ataxia followed by stiff person syndrome three and a half years later. Having both cerebellar ataxia and stiff person syndrome is a rare occurrence in anti-GAD antibody syndrome. We emphasise the importance of long-term follow-up of patients with anti-GAD antibody syndrome, as delayed neurological manifestations can occur. |
| format | Article |
| id | doaj-art-3dd24bbfe5234c5da0273e41a6e62d10 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-3dd24bbfe5234c5da0273e41a6e62d102025-02-03T06:43:39ZengWileyCase Reports in Immunology2090-66092090-66172020-01-01202010.1155/2020/84545328454532Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD AntibodiesSinali O. Seneviratne0Katherine A. Buzzard1Belinda Cruse2Mastura Monif3Curtin University, Kent Street, Bentley, Perth, Western Australia, AustraliaDepartment of Neurology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, AustraliaDepartment of Neurology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, AustraliaDepartment of Neurology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, AustraliaAnti-GAD antibody syndrome is a result of the production of antibodies against glutamic acid decarboxylase (GAD), the main enzyme responsible for the production of gamma-aminobutyric acid (GABA). Several neurological manifestations including cerebellar ataxia and stiff person syndrome have been reported in association with anti-GAD antibodies. In this paper, we present a case of a young woman with anti-GAD antibodies who initially presented with cerebellar ataxia followed by stiff person syndrome three and a half years later. Having both cerebellar ataxia and stiff person syndrome is a rare occurrence in anti-GAD antibody syndrome. We emphasise the importance of long-term follow-up of patients with anti-GAD antibody syndrome, as delayed neurological manifestations can occur.http://dx.doi.org/10.1155/2020/8454532 |
| spellingShingle | Sinali O. Seneviratne Katherine A. Buzzard Belinda Cruse Mastura Monif Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies Case Reports in Immunology |
| title | Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies |
| title_full | Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies |
| title_fullStr | Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies |
| title_full_unstemmed | Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies |
| title_short | Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies |
| title_sort | cerebellar ataxia followed by stiff person syndrome in a patient with anti gad antibodies |
| url | http://dx.doi.org/10.1155/2020/8454532 |
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