Temperature perception by ER UPR promotes preventive innate immunity and longevity
Summary: Microbial infectivity increases with rising environmental temperature, heightening the risk of infection to host organisms. The host’s basal immunity is activated accordingly to mitigate upcoming pathogenic threats; still, how animals sense temperature elevation to adjust their preventive i...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724014220 |
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| author | Lei Zhou Haoyu Zhuo Jiaqi Jin Anrui Pu Qin Liu Jiangbo Song Xiaoling Tong Haiqing Tang Fangyin Dai |
| author_facet | Lei Zhou Haoyu Zhuo Jiaqi Jin Anrui Pu Qin Liu Jiangbo Song Xiaoling Tong Haiqing Tang Fangyin Dai |
| author_sort | Lei Zhou |
| collection | DOAJ |
| description | Summary: Microbial infectivity increases with rising environmental temperature, heightening the risk of infection to host organisms. The host’s basal immunity is activated accordingly to mitigate upcoming pathogenic threats; still, how animals sense temperature elevation to adjust their preventive immune response remains elusive. This study reports that high temperature enhances innate immunity differently from pathogen infection. Unlike pathogen invasion requiring the mitochondrial unfolded protein response (UPR), high temperature engages the endoplasmic reticulum (ER) UPR to trigger the innate immune response. Furthermore, chronic activation of the XBP-1 UPR branch represses nucleolar ribosome biogenesis, a highly energy-consuming process, leading to lipid accumulation. The subsequent increase in oleic acid promotes the activation of the PMK-1 immune pathway. Additionally, ribosome biogenesis was identified as a regulator of longevity, wherein its impact is dependent on lipid metabolism and innate immunity. Collectively, our findings reveal the crucial role of ER-nucleolus crosstalk in shaping preventive immune responses and lifespan regulation. |
| format | Article |
| id | doaj-art-3dccf0dbae914e34a6c539cdf7cd3a80 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-3dccf0dbae914e34a6c539cdf7cd3a802024-12-16T05:35:53ZengElsevierCell Reports2211-12472024-12-014312115071Temperature perception by ER UPR promotes preventive innate immunity and longevityLei Zhou0Haoyu Zhuo1Jiaqi Jin2Anrui Pu3Qin Liu4Jiangbo Song5Xiaoling Tong6Haiqing Tang7Fangyin Dai8State Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, ChinaSchool of Life Sciences, Chongqing University, Chongqing 401331, China; Corresponding authorState Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; Corresponding authorSummary: Microbial infectivity increases with rising environmental temperature, heightening the risk of infection to host organisms. The host’s basal immunity is activated accordingly to mitigate upcoming pathogenic threats; still, how animals sense temperature elevation to adjust their preventive immune response remains elusive. This study reports that high temperature enhances innate immunity differently from pathogen infection. Unlike pathogen invasion requiring the mitochondrial unfolded protein response (UPR), high temperature engages the endoplasmic reticulum (ER) UPR to trigger the innate immune response. Furthermore, chronic activation of the XBP-1 UPR branch represses nucleolar ribosome biogenesis, a highly energy-consuming process, leading to lipid accumulation. The subsequent increase in oleic acid promotes the activation of the PMK-1 immune pathway. Additionally, ribosome biogenesis was identified as a regulator of longevity, wherein its impact is dependent on lipid metabolism and innate immunity. Collectively, our findings reveal the crucial role of ER-nucleolus crosstalk in shaping preventive immune responses and lifespan regulation.http://www.sciencedirect.com/science/article/pii/S2211124724014220CP: ImmunologyCP: Cell biology |
| spellingShingle | Lei Zhou Haoyu Zhuo Jiaqi Jin Anrui Pu Qin Liu Jiangbo Song Xiaoling Tong Haiqing Tang Fangyin Dai Temperature perception by ER UPR promotes preventive innate immunity and longevity Cell Reports CP: Immunology CP: Cell biology |
| title | Temperature perception by ER UPR promotes preventive innate immunity and longevity |
| title_full | Temperature perception by ER UPR promotes preventive innate immunity and longevity |
| title_fullStr | Temperature perception by ER UPR promotes preventive innate immunity and longevity |
| title_full_unstemmed | Temperature perception by ER UPR promotes preventive innate immunity and longevity |
| title_short | Temperature perception by ER UPR promotes preventive innate immunity and longevity |
| title_sort | temperature perception by er upr promotes preventive innate immunity and longevity |
| topic | CP: Immunology CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724014220 |
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