Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study
Abstract Background Cerebral venous sinus thrombosis (CVST) is a rare yet significant neurological disorder with high mortality. Understanding its evolving characteristics, risk factors, and outcomes, particularly in Chinese patients after the COVID-19 pandemic, is critical for developing effective...
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BMC
2025-01-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04019-5 |
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| author | Xiaoming Zhang Kun Fang Duo Lan Xiangqian Huang Xunming Ji Ran Meng Da Zhou |
| author_facet | Xiaoming Zhang Kun Fang Duo Lan Xiangqian Huang Xunming Ji Ran Meng Da Zhou |
| author_sort | Xiaoming Zhang |
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| description | Abstract Background Cerebral venous sinus thrombosis (CVST) is a rare yet significant neurological disorder with high mortality. Understanding its evolving characteristics, risk factors, and outcomes, particularly in Chinese patients after the COVID-19 pandemic, is critical for developing effective preventive and therapeutic strategies. Methods A retrospective analysis was conducted on 471 CVST cases from Xuanwu Hospital, comparing data before (2013–2017, n = 243) and after (2021–2023, n = 228) the COVID-19 pandemic. Data on demographics, clinical features, risk factors, and outcomes were evaluated, with subgroup analyses based on gender and age. Results The mean patient age was 38 ± 14 years, with a female preponderance (55.0%). After the COVID-19 pandemic, significant changes in symptoms and neuroimaging findings were observed, including increased visual impairment and decreased headache, neurological deficits, and seizures. Infection emerged as a prominent risk factor, including eight cases related to COVID-19 or vaccination. At discharge, favorable outcomes (mRS 0–2) were noted in 86.6% of patients. Poor outcomes were associated with central nervous system (CNS) infection, oral contraceptive use or hormone replacement therapy (HRT), hematologic disorders, anemia, and prothrombotic conditions. Anemia was identified as an independent predictor of survival. Conclusions The pandemic has significantly altered the clinical and epidemiological profile of CVST in China. Infections have emerged as key risk factors, while anemia remains a critical prognostic indicator. These findings highlight the need for targeted clinical strategies to improve outcomes. Trial registration This study protocol was reviewed and approved by the ethics committee of Xuanwu Hospital, Capital Medical University (No. 2022-004, dated on November 20, 2022). The clinical trial was registered at Chinese Clinical Trial Registry (ChiCTR2200057621). |
| format | Article |
| id | doaj-art-3dbb3f9d11074a05a2fffade0a7754cc |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-3dbb3f9d11074a05a2fffade0a7754cc2025-01-12T12:28:43ZengBMCBMC Neurology1471-23772025-01-0125111010.1186/s12883-025-04019-5Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative studyXiaoming Zhang0Kun Fang1Duo Lan2Xiangqian Huang3Xunming Ji4Ran Meng5Da Zhou6Department of Neurology, Xuanwu Hospital, Capital Medical UniversityCapital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityAbstract Background Cerebral venous sinus thrombosis (CVST) is a rare yet significant neurological disorder with high mortality. Understanding its evolving characteristics, risk factors, and outcomes, particularly in Chinese patients after the COVID-19 pandemic, is critical for developing effective preventive and therapeutic strategies. Methods A retrospective analysis was conducted on 471 CVST cases from Xuanwu Hospital, comparing data before (2013–2017, n = 243) and after (2021–2023, n = 228) the COVID-19 pandemic. Data on demographics, clinical features, risk factors, and outcomes were evaluated, with subgroup analyses based on gender and age. Results The mean patient age was 38 ± 14 years, with a female preponderance (55.0%). After the COVID-19 pandemic, significant changes in symptoms and neuroimaging findings were observed, including increased visual impairment and decreased headache, neurological deficits, and seizures. Infection emerged as a prominent risk factor, including eight cases related to COVID-19 or vaccination. At discharge, favorable outcomes (mRS 0–2) were noted in 86.6% of patients. Poor outcomes were associated with central nervous system (CNS) infection, oral contraceptive use or hormone replacement therapy (HRT), hematologic disorders, anemia, and prothrombotic conditions. Anemia was identified as an independent predictor of survival. Conclusions The pandemic has significantly altered the clinical and epidemiological profile of CVST in China. Infections have emerged as key risk factors, while anemia remains a critical prognostic indicator. These findings highlight the need for targeted clinical strategies to improve outcomes. Trial registration This study protocol was reviewed and approved by the ethics committee of Xuanwu Hospital, Capital Medical University (No. 2022-004, dated on November 20, 2022). The clinical trial was registered at Chinese Clinical Trial Registry (ChiCTR2200057621).https://doi.org/10.1186/s12883-025-04019-5Cerebral venous sinus thrombosisCOVID-19 pandemicChinese patientsRisk factorsOutcomes |
| spellingShingle | Xiaoming Zhang Kun Fang Duo Lan Xiangqian Huang Xunming Ji Ran Meng Da Zhou Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study BMC Neurology Cerebral venous sinus thrombosis COVID-19 pandemic Chinese patients Risk factors Outcomes |
| title | Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study |
| title_full | Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study |
| title_fullStr | Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study |
| title_full_unstemmed | Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study |
| title_short | Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study |
| title_sort | impact of the covid 19 pandemic on cerebral venous sinus thrombosis in china a comparative study |
| topic | Cerebral venous sinus thrombosis COVID-19 pandemic Chinese patients Risk factors Outcomes |
| url | https://doi.org/10.1186/s12883-025-04019-5 |
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