Effects of Sarcosine (N-methylglycine) on NMDA (N-methyl-D-aspartate) Receptor Hypofunction Induced by MK801: In Vivo Calcium Imaging in the CA1 Region of the Dorsal Hippocampus

Effects of Sarcosine (N-methylglycine) on NMDA (N-methyl-D-aspartate) Receptor Hypofunction Induced by MK801: In Vivo Calcium Imaging in the CA1 Region of the Dorsal Hippocampus

Background: Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective in ameliorating the negative and cognitive symp...

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Main Authors: Yi-Tse Hsiao, Ching-Yuan Chang, Ting-Yen Lee, Wan-Ting Liao, Wen-Sung Lai, Fang-Chia Chang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Brain Sciences
Subjects:
glycine
Miniscope
calcium imaging
schizophrenia
hypofunction model
Online Access:https://www.mdpi.com/2076-3425/14/11/1150
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