Canagliflozin alleviates acetaminophen-induced renal and hepatic injury in mice by modulating the p-GSK3β/Fyn-kinase/Nrf-2 and p-AMPK-α/STAT-3/SOCS-3 pathways

Canagliflozin alleviates acetaminophen-induced renal and hepatic injury in mice by modulating the p-GSK3β/Fyn-kinase/Nrf-2 and p-AMPK-α/STAT-3/SOCS-3 pathways

Abstract Despite the fact that canagliflozin (Cana), a sodium-glucose cotransporter 2 inhibitor, is an anti-diabetic medication with additional effects on the kidney, there is limited experimental data to deliberate its hepato-reno-protective potentiality. Acetaminophen (APAP) overdose remains one o...

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Bibliographic Details
Main Authors: Abeer Bishr, Bassant M. El-Mokadem, Asmaa A. Gomaa
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Acetaminophen
Canagliflozin
Nephrotoxicity
Hepatotoxicity
p-AMPK-α
Fyn-kinase
Online Access:https://doi.org/10.1038/s41598-024-82163-7
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