Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma
Objective: This study aimed to investigate the factors affecting the survival of patients with bone carcinoma metastases and assess the clinical applicability of existing prognostic models. Methods: We retrospectively evaluated 247 patients who presented to our hospital between 2011 and 2021 diag...
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| Format: | Article |
| Language: | English |
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AVES
2024-01-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | https://www.aott.org.tr/en/prognostic-factors-and-real-life-applicability-of-prognostic-models-for-patients-with-bone-metastases-of-carcinoma-137376 |
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| _version_ | 1846162466962145280 |
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| author | Kaan Ali Dalkir Akif Mirioglu Bugra Kundakci Melih Bagir Mehmet Ali Deveci Hilmi Serdar Ozbarlas |
| author_facet | Kaan Ali Dalkir Akif Mirioglu Bugra Kundakci Melih Bagir Mehmet Ali Deveci Hilmi Serdar Ozbarlas |
| author_sort | Kaan Ali Dalkir |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the factors affecting the survival of patients with bone carcinoma metastases and assess the clinical applicability of existing prognostic models.
Methods: We retrospectively evaluated 247 patients who presented to our hospital between 2011 and 2021 diagnosed with bone carcinoma metastasis. Demographic data, general health status, primary diagnoses, laboratory and radiological findings, pathological fracture status, treatment methods, and survival times of the patients were recorded, and the effects of these variables on survival time were evaluated. Previously developed Katagiri, Janssen, 2013-Spring, PathFX, and SORG prognostic models were applied, and the predictive performances of these models were evaluated by comparing the predicted survival time with the actual survival time of our patients.
Results: After the multivariate analysis, the following factors were shown to be significantly associated with the survival time of patients: blood hemoglobin and leukocyte levels, lactate dehydrogenase concentration, prognostic nutritional index, body mass index, performance status, medium and fast-growing groups of primary tumors, presence of extraspinal and visceral or brain metastases, and pathological fractures. According to receiver operating characteristics and Brier scores, SORG had the overall highest performance scores, while the Janssen nomogram had the lowest.
Conclusion: Our report showed that all prognostic models were clinically applicable, but their performances varied. Among them, the SORG predictive model had the best performance scores overall and is the model the authors suggested for survival prediction among patients with carcinoma bone metastases.
Level of Evidence: Level IV, Prognostic Study |
| format | Article |
| id | doaj-art-3d9a1657bff84baebd1135f58726808f |
| institution | Kabale University |
| issn | 1017-995X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj-art-3d9a1657bff84baebd1135f58726808f2024-11-20T09:12:27ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2024-01-01581626710.5152/j.aott.2024.23132Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinomaKaan Ali Dalkir0Akif Mirioglu1Bugra Kundakci2Melih Bagir3Mehmet Ali Deveci4Hilmi Serdar Ozbarlas5Department of Orthopaedics and Traumatology, Viransehir State Hospital, Şanlıurfa, TurkeyDepartment of Orthopaedics and Traumatology, Çukurova University, Adana, TurkeyDepartment of Orthopaedics and Traumatology, Çukurova University, Adana, TurkeyDepartment of Orthopaedics and Traumatology, Çukurova University, Adana, TurkeyDepartment of Orthopaedics and Traumatology, Koç University, İstanbul, TurkeyDepartment of Orthopaedics and Traumatology, Çukurova University, Adana, TurkeyObjective: This study aimed to investigate the factors affecting the survival of patients with bone carcinoma metastases and assess the clinical applicability of existing prognostic models. Methods: We retrospectively evaluated 247 patients who presented to our hospital between 2011 and 2021 diagnosed with bone carcinoma metastasis. Demographic data, general health status, primary diagnoses, laboratory and radiological findings, pathological fracture status, treatment methods, and survival times of the patients were recorded, and the effects of these variables on survival time were evaluated. Previously developed Katagiri, Janssen, 2013-Spring, PathFX, and SORG prognostic models were applied, and the predictive performances of these models were evaluated by comparing the predicted survival time with the actual survival time of our patients. Results: After the multivariate analysis, the following factors were shown to be significantly associated with the survival time of patients: blood hemoglobin and leukocyte levels, lactate dehydrogenase concentration, prognostic nutritional index, body mass index, performance status, medium and fast-growing groups of primary tumors, presence of extraspinal and visceral or brain metastases, and pathological fractures. According to receiver operating characteristics and Brier scores, SORG had the overall highest performance scores, while the Janssen nomogram had the lowest. Conclusion: Our report showed that all prognostic models were clinically applicable, but their performances varied. Among them, the SORG predictive model had the best performance scores overall and is the model the authors suggested for survival prediction among patients with carcinoma bone metastases. Level of Evidence: Level IV, Prognostic Studyhttps://www.aott.org.tr/en/prognostic-factors-and-real-life-applicability-of-prognostic-models-for-patients-with-bone-metastases-of-carcinoma-137376 |
| spellingShingle | Kaan Ali Dalkir Akif Mirioglu Bugra Kundakci Melih Bagir Mehmet Ali Deveci Hilmi Serdar Ozbarlas Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma Acta Orthopaedica et Traumatologica Turcica |
| title | Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma |
| title_full | Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma |
| title_fullStr | Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma |
| title_full_unstemmed | Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma |
| title_short | Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma |
| title_sort | prognostic factors and real life applicability of prognostic models for patients with bone metastases of carcinoma |
| url | https://www.aott.org.tr/en/prognostic-factors-and-real-life-applicability-of-prognostic-models-for-patients-with-bone-metastases-of-carcinoma-137376 |
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