Unlocking the mysteries of n-oxPTH: implications for CKD patients
Parathyroid hormone (PTH) is a pivotal hormone that regulates serum calcium and phosphate and is closely associated with higher risk of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). PTH can undergo oxidation at methionine 8 and methionine 18 of the molecule. Thi...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1455783/full |
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| author | Lina Zhang Huixia Cao |
| author_facet | Lina Zhang Huixia Cao |
| author_sort | Lina Zhang |
| collection | DOAJ |
| description | Parathyroid hormone (PTH) is a pivotal hormone that regulates serum calcium and phosphate and is closely associated with higher risk of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). PTH can undergo oxidation at methionine 8 and methionine 18 of the molecule. This oxidation process leads to a lower binding affinity to the PTH receptor due to molecular refolding, particularly for PTH oxidized at methionine 8. Although, the oxidation of PTH has been reported for several decades, it is only recently that a method has been developed to detect non-oxidized PTH (n-oxPTH) levels. The utilization of this assay enables the precise detection of n-oxPTH levels and facilitates the evaluation of their correlation with poor prognosis in patients with CKD. However, the current available clinical research findings indicate that n-oxPTH does not demonstrate clinical superiority over iPTH. Here, we provide a comprehensive review on the mechanism of PTH oxidation, the n-oxPTH assay method, and its correlation with iPTH and clinical outcomes. |
| format | Article |
| id | doaj-art-3d96fc85840b4705b7d5f523a0b956b3 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-3d96fc85840b4705b7d5f523a0b956b32025-01-03T05:10:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14557831455783Unlocking the mysteries of n-oxPTH: implications for CKD patientsLina ZhangHuixia CaoParathyroid hormone (PTH) is a pivotal hormone that regulates serum calcium and phosphate and is closely associated with higher risk of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). PTH can undergo oxidation at methionine 8 and methionine 18 of the molecule. This oxidation process leads to a lower binding affinity to the PTH receptor due to molecular refolding, particularly for PTH oxidized at methionine 8. Although, the oxidation of PTH has been reported for several decades, it is only recently that a method has been developed to detect non-oxidized PTH (n-oxPTH) levels. The utilization of this assay enables the precise detection of n-oxPTH levels and facilitates the evaluation of their correlation with poor prognosis in patients with CKD. However, the current available clinical research findings indicate that n-oxPTH does not demonstrate clinical superiority over iPTH. Here, we provide a comprehensive review on the mechanism of PTH oxidation, the n-oxPTH assay method, and its correlation with iPTH and clinical outcomes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1455783/fulloxidizedparathyroid hormonechronic kidney diseaseprognosisimmunoassay |
| spellingShingle | Lina Zhang Huixia Cao Unlocking the mysteries of n-oxPTH: implications for CKD patients Frontiers in Endocrinology oxidized parathyroid hormone chronic kidney disease prognosis immunoassay |
| title | Unlocking the mysteries of n-oxPTH: implications for CKD patients |
| title_full | Unlocking the mysteries of n-oxPTH: implications for CKD patients |
| title_fullStr | Unlocking the mysteries of n-oxPTH: implications for CKD patients |
| title_full_unstemmed | Unlocking the mysteries of n-oxPTH: implications for CKD patients |
| title_short | Unlocking the mysteries of n-oxPTH: implications for CKD patients |
| title_sort | unlocking the mysteries of n oxpth implications for ckd patients |
| topic | oxidized parathyroid hormone chronic kidney disease prognosis immunoassay |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1455783/full |
| work_keys_str_mv | AT linazhang unlockingthemysteriesofnoxpthimplicationsforckdpatients AT huixiacao unlockingthemysteriesofnoxpthimplicationsforckdpatients |