OncoTrace‐TOO: Interpretable Machine Learning Framework for Cancer Tissue‐of‐Origin Identification Using Transcriptomic Signatures

OncoTrace‐TOO: Interpretable Machine Learning Framework for Cancer Tissue‐of‐Origin Identification Using Transcriptomic Signatures

ABSTRACT Background Cancer of unknown primary remains a formidable diagnostic challenge due to the inability to pinpoint the primary tumor site, which restricts the use of targeted therapeutics. Although machine‐learning methods that integrate transcriptomic approaches have provided valuable insight...

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Bibliographic Details
Main Authors: Yang Hao, Haochun Huang, Daiyun Huang, Jianwen Ruan, Xin Liu, Jianquan Zhang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Reports
Subjects:
cancer of unknown primary
machine learning
metastasis
tissue‐of‐origin identification
transcriptomics
Online Access:https://doi.org/10.1002/cnr2.70311
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