Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells

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Main Authors: Xinyi Tao, Li Zou, Wenxin Fang, Ruolan Zhang, Jianhui Liang, Yan Wang, Lei Chen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000899
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author Xinyi Tao
Li Zou
Wenxin Fang
Ruolan Zhang
Jianhui Liang
Yan Wang
Lei Chen
author_facet Xinyi Tao
Li Zou
Wenxin Fang
Ruolan Zhang
Jianhui Liang
Yan Wang
Lei Chen
author_sort Xinyi Tao
collection DOAJ
format Article
id doaj-art-3d59a3be537146d4ac09c7f81b5ca8dd
institution Kabale University
issn 2211-3835
language English
publishDate 2025-04-01
publisher Elsevier
record_format Article
series Acta Pharmaceutica Sinica B
spelling doaj-art-3d59a3be537146d4ac09c7f81b5ca8dd2025-08-20T03:49:03ZengElsevierActa Pharmaceutica Sinica B2211-38352025-04-011542278228210.1016/j.apsb.2025.02.016Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cellsXinyi Tao0Li Zou1Wenxin Fang2Ruolan Zhang3Jianhui Liang4Yan Wang5Lei Chen6School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, ChinaSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, ChinaSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, ChinaSchool of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, ChinaCenter for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Corresponding authors.School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, China; Institute of Microphysiological Systems, Southeast University, Nanjing 211189, China; Corresponding authors.http://www.sciencedirect.com/science/article/pii/S2211383525000899TPDPROTACMolecular glueCancerOncology drugscRNA-seq
spellingShingle Xinyi Tao
Li Zou
Wenxin Fang
Ruolan Zhang
Jianhui Liang
Yan Wang
Lei Chen
Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
Acta Pharmaceutica Sinica B
TPD
PROTAC
Molecular glue
Cancer
Oncology drug
scRNA-seq
title Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
title_full Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
title_fullStr Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
title_full_unstemmed Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
title_short Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
title_sort optimizing tpd based oncology drug development the critical role of pdr distribution in poi positive cancer cells
topic TPD
PROTAC
Molecular glue
Cancer
Oncology drug
scRNA-seq
url http://www.sciencedirect.com/science/article/pii/S2211383525000899
work_keys_str_mv AT xinyitao optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells
AT lizou optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells
AT wenxinfang optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells
AT ruolanzhang optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells
AT jianhuiliang optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells
AT yanwang optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells
AT leichen optimizingtpdbasedoncologydrugdevelopmentthecriticalroleofpdrdistributioninpoipositivecancercells