Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>)
The increasing demand for sustainable disease management in aquaculture has intensified interest in plant-based therapeutics. This study evaluated the formulation and efficacy of andrographolide-loaded nanostructured lipid carriers (AND-NLCs) in Nile tilapia (<i data-eusoft-scrollable-element=&qu...
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MDPI AG
2025-07-01
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| author | Warut Kengkittipat Manoj Tukaram Kamble Sirikorn Kitiyodom Jakarwan Yostawonkul Gotchagorn Sawatphakdee Kim D. Thompson Seema Vijay Medhe Nopadon Pirarat |
| author_facet | Warut Kengkittipat Manoj Tukaram Kamble Sirikorn Kitiyodom Jakarwan Yostawonkul Gotchagorn Sawatphakdee Kim D. Thompson Seema Vijay Medhe Nopadon Pirarat |
| author_sort | Warut Kengkittipat |
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| description | The increasing demand for sustainable disease management in aquaculture has intensified interest in plant-based therapeutics. This study evaluated the formulation and efficacy of andrographolide-loaded nanostructured lipid carriers (AND-NLCs) in Nile tilapia (<i data-eusoft-scrollable-element="1">Oreochromis niloticus</i>) challenged with <i data-eusoft-scrollable-element="1">Streptococcus agalactiae</i> ENC06. AND-NLCs were prepared by the phase-inversion technique and characterized by dynamic light scattering, transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and in vitro release profiling. Antibacterial activity was assessed by measuring inhibition zone diameters, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). Growth performance, feed utilization, hepatosomatic index (HSI), and disease resistance were evaluated over a 60-day feeding trial. The AND-NLCs exhibited an optimal particle size (189.6 nm), high encapsulation efficiency (90.58%), sustained release, and structural stability. Compared to the free AND and control group, AND-NLC supplementation significantly improved growth, feed efficiency, HSI, and positive allometric growth. It also enhanced survival (73.3%) and relative percent survival (RPS = 65.6%) following <i data-eusoft-scrollable-element="1">S. agalactiae</i> ENC06 infection. Antibacterial efficacy and physiological responses showed positive correlations with nanoparticle characteristics. These findings suggest that AND-NLCs enhance bioavailability and therapeutic efficacy, supporting their potential as a functional dietary additive to promote growth and improve disease resistance in tilapia aquaculture. |
| format | Article |
| id | doaj-art-3d52c1ddfead49da8f77558d24b76ac1 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-3d52c1ddfead49da8f77558d24b76ac12025-08-20T03:55:49ZengMDPI AGAnimals2076-26152025-07-011514211710.3390/ani15142117Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>)Warut Kengkittipat0Manoj Tukaram Kamble1Sirikorn Kitiyodom2Jakarwan Yostawonkul3Gotchagorn Sawatphakdee4Kim D. Thompson5Seema Vijay Medhe6Nopadon Pirarat7International Graduate Course of Veterinary Science and Technology (VST), Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Wildlife, Exotic, and Aquatic Animal Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Wildlife, Exotic, and Aquatic Animal Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12120, ThailandCenter of Excellence in Wildlife, Exotic, and Aquatic Animal Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandMoredun Research Institute, Penicuik EH26 0PZ, UKASEAN Institute for Health Development, Mahidol University, Salaya, Putthamonthon, Nakhon Pathom 73170, ThailandCenter of Excellence in Wildlife, Exotic, and Aquatic Animal Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, ThailandThe increasing demand for sustainable disease management in aquaculture has intensified interest in plant-based therapeutics. This study evaluated the formulation and efficacy of andrographolide-loaded nanostructured lipid carriers (AND-NLCs) in Nile tilapia (<i data-eusoft-scrollable-element="1">Oreochromis niloticus</i>) challenged with <i data-eusoft-scrollable-element="1">Streptococcus agalactiae</i> ENC06. AND-NLCs were prepared by the phase-inversion technique and characterized by dynamic light scattering, transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and in vitro release profiling. Antibacterial activity was assessed by measuring inhibition zone diameters, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). Growth performance, feed utilization, hepatosomatic index (HSI), and disease resistance were evaluated over a 60-day feeding trial. The AND-NLCs exhibited an optimal particle size (189.6 nm), high encapsulation efficiency (90.58%), sustained release, and structural stability. Compared to the free AND and control group, AND-NLC supplementation significantly improved growth, feed efficiency, HSI, and positive allometric growth. It also enhanced survival (73.3%) and relative percent survival (RPS = 65.6%) following <i data-eusoft-scrollable-element="1">S. agalactiae</i> ENC06 infection. Antibacterial efficacy and physiological responses showed positive correlations with nanoparticle characteristics. These findings suggest that AND-NLCs enhance bioavailability and therapeutic efficacy, supporting their potential as a functional dietary additive to promote growth and improve disease resistance in tilapia aquaculture.https://www.mdpi.com/2076-2615/15/14/2117Nile tilapiaandrographolidenanostructured lipid carriers (NLCs)<i>Streptococcus agalactiae</i>aquacultureantibacterial activity |
| spellingShingle | Warut Kengkittipat Manoj Tukaram Kamble Sirikorn Kitiyodom Jakarwan Yostawonkul Gotchagorn Sawatphakdee Kim D. Thompson Seema Vijay Medhe Nopadon Pirarat Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>) Animals Nile tilapia andrographolide nanostructured lipid carriers (NLCs) <i>Streptococcus agalactiae</i> aquaculture antibacterial activity |
| title | Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>) |
| title_full | Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>) |
| title_fullStr | Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>) |
| title_full_unstemmed | Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>) |
| title_short | Effects of Andrographolide-Loaded Nanostructured Lipid Carriers on Growth, Feed Efficiency, and Resistance to <i>Streptococcus agalactiae</i> in Nile Tilapia (<i>Oreochromis niloticus</i>) |
| title_sort | effects of andrographolide loaded nanostructured lipid carriers on growth feed efficiency and resistance to i streptococcus agalactiae i in nile tilapia i oreochromis niloticus i |
| topic | Nile tilapia andrographolide nanostructured lipid carriers (NLCs) <i>Streptococcus agalactiae</i> aquaculture antibacterial activity |
| url | https://www.mdpi.com/2076-2615/15/14/2117 |
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