Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022)
Abstract Background The aim of this study was to evaluate the association between simple, combined lipid biomarkers, and 20-year cumulative incidence of new type 2 diabetes mellitus (T2DM) among adults participating in the ATTICA cohort study (2002–2022). Methods The present analysis included data f...
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BMC
2024-12-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-024-02383-8 |
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| author | Ioanna Kechagia Fotios Barkas Evangelos Liberopoulos Christina Chrysohoou Petros P. Sfikakis Costas Tsioufis Christos Pitsavos Demosthenes Panagiotakos |
| author_facet | Ioanna Kechagia Fotios Barkas Evangelos Liberopoulos Christina Chrysohoou Petros P. Sfikakis Costas Tsioufis Christos Pitsavos Demosthenes Panagiotakos |
| author_sort | Ioanna Kechagia |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to evaluate the association between simple, combined lipid biomarkers, and 20-year cumulative incidence of new type 2 diabetes mellitus (T2DM) among adults participating in the ATTICA cohort study (2002–2022). Methods The present analysis included data from 2000 individuals free of T2DM at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations; combined lipid markers were evaluated. Results The 20-year cumulative incidence of T2DM was 26.3% (95%CI 24.4, 28.3%). All, simple and combined lipid markers were independently associated with new T2DM onset. The accuracy of simple and combined markers was approximately 75%, without any significant differences between simple and combined indices. The additive correct classification gain of lipid markers to glucose metabolism indices on 20-year new T2DM cumulative incidence varied between 0.9% for cardiometabolic index to 10.6% for LDL-cholesterol. Conclusions Lipid profile is associated with the long-term onset of T2DM. Evaluated through simple or combined markers, lipid profiles can be utilized for identifying and improving risk stratification in individuals at high risk for T2DM, while also enhancing the effectiveness of primary prevention measures and public health strategies. |
| format | Article |
| id | doaj-art-3d04e77e11c94e9cbcf7af080cd310cb |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-3d04e77e11c94e9cbcf7af080cd310cb2024-12-22T12:44:53ZengBMCLipids in Health and Disease1476-511X2024-12-0123111010.1186/s12944-024-02383-8Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022)Ioanna Kechagia0Fotios Barkas1Evangelos Liberopoulos2Christina Chrysohoou3Petros P. Sfikakis4Costas Tsioufis5Christos Pitsavos6Demosthenes Panagiotakos7Department of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio UniversityDepartment of Internal Medicine, Medical School, University of IoanninaFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General HospitalFirst Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration HospitalFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General HospitalFirst Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration HospitalFirst Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration HospitalDepartment of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio UniversityAbstract Background The aim of this study was to evaluate the association between simple, combined lipid biomarkers, and 20-year cumulative incidence of new type 2 diabetes mellitus (T2DM) among adults participating in the ATTICA cohort study (2002–2022). Methods The present analysis included data from 2000 individuals free of T2DM at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations; combined lipid markers were evaluated. Results The 20-year cumulative incidence of T2DM was 26.3% (95%CI 24.4, 28.3%). All, simple and combined lipid markers were independently associated with new T2DM onset. The accuracy of simple and combined markers was approximately 75%, without any significant differences between simple and combined indices. The additive correct classification gain of lipid markers to glucose metabolism indices on 20-year new T2DM cumulative incidence varied between 0.9% for cardiometabolic index to 10.6% for LDL-cholesterol. Conclusions Lipid profile is associated with the long-term onset of T2DM. Evaluated through simple or combined markers, lipid profiles can be utilized for identifying and improving risk stratification in individuals at high risk for T2DM, while also enhancing the effectiveness of primary prevention measures and public health strategies.https://doi.org/10.1186/s12944-024-02383-8Lipid markersMediterranean dietIncidenceType 2 diabetes mellitus |
| spellingShingle | Ioanna Kechagia Fotios Barkas Evangelos Liberopoulos Christina Chrysohoou Petros P. Sfikakis Costas Tsioufis Christos Pitsavos Demosthenes Panagiotakos Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022) Lipids in Health and Disease Lipid markers Mediterranean diet Incidence Type 2 diabetes mellitus |
| title | Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022) |
| title_full | Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022) |
| title_fullStr | Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022) |
| title_full_unstemmed | Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022) |
| title_short | Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022) |
| title_sort | association between simple combined lipid markers and 20 year cumulative incidence of type 2 diabetes the attica cohort study 2002 2022 |
| topic | Lipid markers Mediterranean diet Incidence Type 2 diabetes mellitus |
| url | https://doi.org/10.1186/s12944-024-02383-8 |
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