Role of Lipoic Acid in Testosterone Production in Males
Testosterone extends its impact beyond sexual function, playing a crucial role in shaping overall male health, including aspects such as muscle mass, bone density, mood regulation, and energy levels. Lipoic acid, a cofactor for specific enzymes, particularly dehydrogenases involved in cellular ene...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2025-01-01
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| Series: | The World Journal of Men's Health |
| Subjects: | |
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| Summary: | Testosterone extends its impact beyond sexual function, playing a crucial role in shaping overall male health, including aspects
such as muscle mass, bone density, mood regulation, and energy levels. Lipoic acid, a cofactor for specific enzymes,
particularly dehydrogenases involved in cellular energy production, has been studied for its impact on testosterone. This
comprehensive review systematically scoured PubMed and Scopus databases using the keywords “lipoic acid” and “testosterone.”
It encompassed all relevant English papers published from November 1971 to the present, including full texts and
abstracts, along with research elucidating the biochemical mechanisms linking lipoic acid to testosterone. In summary, lipoic
acid consistently restores testosterone levels, offering promise as an intervention in testicular health, especially in cases of
testicular toxicity caused by various harmful agents. Its mechanisms encompass nitric oxide enhancement, fortification of
testicular antioxidants, elevation of luteinizing hormone, enhancement of steroidogenesis, and the maintenance of energy
production. These mechanisms underscore the therapeutic potential of lipoic acid for testicular health. |
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| ISSN: | 2287-4208 2287-4690 |