Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis.

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis.

<h4>Background</h4>Aberrations in the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/AKT pathway are common in solid tumors. Numerous drugs have been developed to target different components of this pathway. However the prognostic value of these aberrations is...

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Main Authors: Alberto Ocana, Francisco Vera-Badillo, Mustafa Al-Mubarak, Arnoud J Templeton, Verónica Corrales-Sanchez, Laura Diez-Gonzalez, María D Cuenca-Lopez, Bostjan Seruga, Atanasio Pandiella, Eitan Amir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0095219
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