Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection
We present comparative analysis of clinical – morphological data from infants with congenital cytomegalovirus and hepatitis C infection. 97 patients with hepatitis underwent a standard set of clinical and laboratory tests. ELISA and PCR were used to verify infectious agents. Informed consent to perf...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/149 |
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| author | R. A. Ushakova O. P. Kovtun I. E. Valamina N. B. Blinkova Ya. M. Krohaleva L. M. Ziguleva M. A. Shvarts S. N. Tuponogov A. M. Nikolaeva |
| author_facet | R. A. Ushakova O. P. Kovtun I. E. Valamina N. B. Blinkova Ya. M. Krohaleva L. M. Ziguleva M. A. Shvarts S. N. Tuponogov A. M. Nikolaeva |
| author_sort | R. A. Ushakova |
| collection | DOAJ |
| description | We present comparative analysis of clinical – morphological data from infants with congenital cytomegalovirus and hepatitis C infection. 97 patients with hepatitis underwent a standard set of clinical and laboratory tests. ELISA and PCR were used to verify infectious agents. Informed consent to perform a liver biopsy was obtained from the parents of 28 children. immunohistochemical test of the liver samples managed to identify markers of cytomegalovirus (protein pp65 and p52) and hepatitis C (helicase NS3). The hepatitis C virus was detected in 41 patients: 3a genotype – 68.3%, 1b –31.7% respectively. Congenital hepatitis C onset presents itself as mild and atypical and causes chronic hepatitis with the 1st degree fibrosis. Cytomegalovirus replication markers were found in 56 children. The most common manifestations of hepatitis associated with cytomegalovirus infection are prolonged jaundice, cholestasis, gepatolienalny syndrome, early onset of the disease with increased transaminase levels and dominance in AST. Structural changes of the liver are characterized by the presence of inflammatory infiltration, cholestasis with duktulopenia, lobular structure damage. Congenital cytomegalovirus-related hepatitis is likely to result in liver cirrhosis and is associated with poor prognosis. |
| format | Article |
| id | doaj-art-3cecdc4fa8db4551a48e4632e3413c1b |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-3cecdc4fa8db4551a48e4632e3413c1b2025-08-20T03:44:24ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0151283410.22625/2072-6732-2013-5-1-28-34163Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infectionR. A. Ushakova0O. P. Kovtun1I. E. Valamina2N. B. Blinkova3Ya. M. Krohaleva4L. M. Ziguleva5M. A. Shvarts6S. N. Tuponogov7A. M. Nikolaeva8Ural State Medical Academy, YekaterinburgUral State Medical Academy, YekaterinburgUral State Medical Academy, YekaterinburgUral State Medical Academy, Yekaterinburg Ural Department of Russian Academy of Sciences, YekaterinburgSverdlovsk Regional Pathologic Anatomic office, YekaterinburgRegional Clinical Hospital № 1, YekaterinburgRegional Clinical Hospital № 1, YekaterinburgRegional Clinical Hospital № 1, YekaterinburgRegional Clinical Hospital № 1, YekaterinburgWe present comparative analysis of clinical – morphological data from infants with congenital cytomegalovirus and hepatitis C infection. 97 patients with hepatitis underwent a standard set of clinical and laboratory tests. ELISA and PCR were used to verify infectious agents. Informed consent to perform a liver biopsy was obtained from the parents of 28 children. immunohistochemical test of the liver samples managed to identify markers of cytomegalovirus (protein pp65 and p52) and hepatitis C (helicase NS3). The hepatitis C virus was detected in 41 patients: 3a genotype – 68.3%, 1b –31.7% respectively. Congenital hepatitis C onset presents itself as mild and atypical and causes chronic hepatitis with the 1st degree fibrosis. Cytomegalovirus replication markers were found in 56 children. The most common manifestations of hepatitis associated with cytomegalovirus infection are prolonged jaundice, cholestasis, gepatolienalny syndrome, early onset of the disease with increased transaminase levels and dominance in AST. Structural changes of the liver are characterized by the presence of inflammatory infiltration, cholestasis with duktulopenia, lobular structure damage. Congenital cytomegalovirus-related hepatitis is likely to result in liver cirrhosis and is associated with poor prognosis.https://journal.niidi.ru/jofin/article/view/149infantsjaundicecholestasiscongenital hepatitis ccytomegalovirus hepatitiscirrhosis |
| spellingShingle | R. A. Ushakova O. P. Kovtun I. E. Valamina N. B. Blinkova Ya. M. Krohaleva L. M. Ziguleva M. A. Shvarts S. N. Tuponogov A. M. Nikolaeva Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection Журнал инфектологии infants jaundice cholestasis congenital hepatitis c cytomegalovirus hepatitis cirrhosis |
| title | Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection |
| title_full | Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection |
| title_fullStr | Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection |
| title_full_unstemmed | Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection |
| title_short | Clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis C infection |
| title_sort | clinical and morphological variants of hepatitis onset with congenital cytomegalovirus and hepatitis c infection |
| topic | infants jaundice cholestasis congenital hepatitis c cytomegalovirus hepatitis cirrhosis |
| url | https://journal.niidi.ru/jofin/article/view/149 |
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