Neonatal infection with Bordetella pertussis promotes autism-like phenotypes in mice

Neonatal infection with Bordetella pertussis promotes autism-like phenotypes in mice

Summary: Autism spectrum disorder (ASD) has been linked with infections early in life. Here we demonstrate that the infection of neonatal mice with the respiratory pathogen Bordetella pertussis leads to neuroinflammation, neurodevelopmental defects, and ASD-like behaviors. Following the respiratory...

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Bibliographic Details
Main Authors: Eoin O’Neill, Lucy Curham, Caitlín Ní Chasaide, Síofra O’Brien, Gavin McManus, Barry Moran, Keith Rubin, Steven Glazer, Marina A. Lynch, Kingston H.G. Mills
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Neuroscience
Behavioral neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027755
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