Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease
Background The effect of microwave ablation (MWA) for the renal cell carcinoma (RCC) in Von Hippel-Lindau (VHL) disease is unclear.Objective To assess the safety, Technique efficacy, renal function and oncological outcome of MWA for RCC in VHL patients.Methods Consecutive patients with RCCs in VHL d...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2308079 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560885208809472 |
|---|---|
| author | Jiye Chen Lin Zheng Wei Zhang Zhen Wang Jie Yu Ping Liang |
| author_facet | Jiye Chen Lin Zheng Wei Zhang Zhen Wang Jie Yu Ping Liang |
| author_sort | Jiye Chen |
| collection | DOAJ |
| description | Background The effect of microwave ablation (MWA) for the renal cell carcinoma (RCC) in Von Hippel-Lindau (VHL) disease is unclear.Objective To assess the safety, Technique efficacy, renal function and oncological outcome of MWA for RCC in VHL patients.Methods Consecutive patients with RCCs in VHL disease treated by MWA were retrospectively collected from November 2009 to October 2020. The technical efficacy rate and complications were assessed. The outcomes of pre- and post-ablative eGFR were compared. The local recurrent-free survival (LRFS), renal-cancer-free survival (RCFS), cancer-specific survival (CSS), overall survival (OS) and complications were presented.Results A total of 10 patients (mean age, 39.0 years ± 10.7 [SD]; 3 women) with 28 RCCs (mean tumor size, 3.0 cm ± 0.34; mean tumor volume, 20.7 mL ± 43.3) treated with MWA were included. Th median follow-up time was 52 months(IQR:27-80). The overall technical efficacy rate was 100% with no major complications occurred. No significant statistical difference between pre-ablative and postablative creatinine level (102.0 µmol/L ± 30.4 vs 112.3 µmol/L ± 38.7, p = 0.06), but the pre-ablative eGFR level was significantly higher than the post-ablative eGFR (78.0 mL/(min*1.73m2) ± 28.6 vs 72 mL/(min*1.73m2) ± 31.4, p = 0.04), with the mean decrease of 5.86 ml/(min*1.73m2). The local recurrent-free survival(LRFS) and renal-cancer-free survival (RCFS) were 100% and 60%, respectively. The cancer specifical survival (CSS) and overall survival (OS) were 95.5% and 100%, respectively.Conclusion Microwave ablation is a safe and feasible method for the treatment of RCC in VHL disease, preserving renal function and yielding satisfactory oncological outcomes. |
| format | Article |
| id | doaj-art-3ccea7228ca14485a3d7e0544bb0265a |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-3ccea7228ca14485a3d7e0544bb0265a2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2308079Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau diseaseJiye Chen0Lin Zheng1Wei Zhang2Zhen Wang3Jie Yu4Ping Liang5Department of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaUltrasound Diagnostic Department, 92493 Military Hospital of the Chinese People’s Liberation Army, Beijing; China.Department of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaBackground The effect of microwave ablation (MWA) for the renal cell carcinoma (RCC) in Von Hippel-Lindau (VHL) disease is unclear.Objective To assess the safety, Technique efficacy, renal function and oncological outcome of MWA for RCC in VHL patients.Methods Consecutive patients with RCCs in VHL disease treated by MWA were retrospectively collected from November 2009 to October 2020. The technical efficacy rate and complications were assessed. The outcomes of pre- and post-ablative eGFR were compared. The local recurrent-free survival (LRFS), renal-cancer-free survival (RCFS), cancer-specific survival (CSS), overall survival (OS) and complications were presented.Results A total of 10 patients (mean age, 39.0 years ± 10.7 [SD]; 3 women) with 28 RCCs (mean tumor size, 3.0 cm ± 0.34; mean tumor volume, 20.7 mL ± 43.3) treated with MWA were included. Th median follow-up time was 52 months(IQR:27-80). The overall technical efficacy rate was 100% with no major complications occurred. No significant statistical difference between pre-ablative and postablative creatinine level (102.0 µmol/L ± 30.4 vs 112.3 µmol/L ± 38.7, p = 0.06), but the pre-ablative eGFR level was significantly higher than the post-ablative eGFR (78.0 mL/(min*1.73m2) ± 28.6 vs 72 mL/(min*1.73m2) ± 31.4, p = 0.04), with the mean decrease of 5.86 ml/(min*1.73m2). The local recurrent-free survival(LRFS) and renal-cancer-free survival (RCFS) were 100% and 60%, respectively. The cancer specifical survival (CSS) and overall survival (OS) were 95.5% and 100%, respectively.Conclusion Microwave ablation is a safe and feasible method for the treatment of RCC in VHL disease, preserving renal function and yielding satisfactory oncological outcomes.https://www.tandfonline.com/doi/10.1080/02656736.2024.2308079Microwave ablationrenal cell carcinomaoverall survivalvon Hippel–Lindau (VHL) disease |
| spellingShingle | Jiye Chen Lin Zheng Wei Zhang Zhen Wang Jie Yu Ping Liang Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease International Journal of Hyperthermia Microwave ablation renal cell carcinoma overall survival von Hippel–Lindau (VHL) disease |
| title | Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease |
| title_full | Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease |
| title_fullStr | Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease |
| title_full_unstemmed | Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease |
| title_short | Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel–Lindau disease |
| title_sort | percutaneous microwave ablation on management of hereditary renal cell carcinoma in von hippel lindau disease |
| topic | Microwave ablation renal cell carcinoma overall survival von Hippel–Lindau (VHL) disease |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2308079 |
| work_keys_str_mv | AT jiyechen percutaneousmicrowaveablationonmanagementofhereditaryrenalcellcarcinomainvonhippellindaudisease AT linzheng percutaneousmicrowaveablationonmanagementofhereditaryrenalcellcarcinomainvonhippellindaudisease AT weizhang percutaneousmicrowaveablationonmanagementofhereditaryrenalcellcarcinomainvonhippellindaudisease AT zhenwang percutaneousmicrowaveablationonmanagementofhereditaryrenalcellcarcinomainvonhippellindaudisease AT jieyu percutaneousmicrowaveablationonmanagementofhereditaryrenalcellcarcinomainvonhippellindaudisease AT pingliang percutaneousmicrowaveablationonmanagementofhereditaryrenalcellcarcinomainvonhippellindaudisease |