Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome
The relationship of heavy alcohol consumption (HAC) and smoking to mortality in those with CHD, and mechanisms through which these effects are elicited are not clear. In order to improve our understanding, we examined the relationship of Alcohol T-Scores (ATS), an epigenetic biomarker of chronic HAC...
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Taylor & Francis Group
2024-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2024.2433833 |
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| author | Allan Andersen Steven R. H. Beach Willem Philibert James A. Mills Emily Milefchik Emma Papworth Kelsey Dawes Joanna Moody Gracie Weeks Ellyse Froehlich Kaitlyn deBlois Jeffrey D. Long Ferhaan Ahmad Robert Philibert |
| author_facet | Allan Andersen Steven R. H. Beach Willem Philibert James A. Mills Emily Milefchik Emma Papworth Kelsey Dawes Joanna Moody Gracie Weeks Ellyse Froehlich Kaitlyn deBlois Jeffrey D. Long Ferhaan Ahmad Robert Philibert |
| author_sort | Allan Andersen |
| collection | DOAJ |
| description | The relationship of heavy alcohol consumption (HAC) and smoking to mortality in those with CHD, and mechanisms through which these effects are elicited are not clear. In order to improve our understanding, we examined the relationship of Alcohol T-Scores (ATS), an epigenetic biomarker of chronic HAC, and cg05575921 methylation, a biomarker of smoking intensity, with all-cause mortality and degree of coronary artery obstruction in a cohort of 217 subjects admitted for CHD-related acute coronary syndrome (ACS). We found that 65% of the subjects had ATS values indicative of chronic HAC. ATS values, but not cg05575921 values, were significantly associated (p < 0.02) with subsequent proband death (total of 28 deaths) with a Cox Proportional Hazards model showing a slightly larger effect of ATS levels than age on all-cause mortality survival (overall model, p < 0.003). Subjects in the highest decile of ATS scores had a 2.4-fold increase in the risk for mortality as compared to those in the lowest decile. In contrast, cg05575921 methylation (p < 0.003) but not ATS scores, were significantly inversely associated with degree of obstruction. Only 2 of the 217 subjects were referred for treatment for either smoking or drinking. We conclude that HAC is an underappreciated driver of CHD-related mortality, that those with ACS who smoke are much less likely to have significant obstruction upon cardiac imaging and that substance use treatment may be underutilized in those with CHD. |
| format | Article |
| id | doaj-art-3cb911f9c7014d9191568691974c51a6 |
| institution | Kabale University |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-3cb911f9c7014d9191568691974c51a62024-12-09T07:21:36ZengTaylor & Francis GroupEpigenetics1559-22941559-23082024-12-0119110.1080/15592294.2024.2433833Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndromeAllan Andersen0Steven R. H. Beach1Willem Philibert2James A. Mills3Emily Milefchik4Emma Papworth5Kelsey Dawes6Joanna Moody7Gracie Weeks8Ellyse Froehlich9Kaitlyn deBlois10Jeffrey D. Long11Ferhaan Ahmad12Robert Philibert13Department of Psychiatry, University of Iowa, Iowa City, IA, USACenter for Family Research/Department of Psychology, University of Georgia, Athens, GA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USADepartment of Biostatistics, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, University of Iowa, Iowa City, IA, USAThe relationship of heavy alcohol consumption (HAC) and smoking to mortality in those with CHD, and mechanisms through which these effects are elicited are not clear. In order to improve our understanding, we examined the relationship of Alcohol T-Scores (ATS), an epigenetic biomarker of chronic HAC, and cg05575921 methylation, a biomarker of smoking intensity, with all-cause mortality and degree of coronary artery obstruction in a cohort of 217 subjects admitted for CHD-related acute coronary syndrome (ACS). We found that 65% of the subjects had ATS values indicative of chronic HAC. ATS values, but not cg05575921 values, were significantly associated (p < 0.02) with subsequent proband death (total of 28 deaths) with a Cox Proportional Hazards model showing a slightly larger effect of ATS levels than age on all-cause mortality survival (overall model, p < 0.003). Subjects in the highest decile of ATS scores had a 2.4-fold increase in the risk for mortality as compared to those in the lowest decile. In contrast, cg05575921 methylation (p < 0.003) but not ATS scores, were significantly inversely associated with degree of obstruction. Only 2 of the 217 subjects were referred for treatment for either smoking or drinking. We conclude that HAC is an underappreciated driver of CHD-related mortality, that those with ACS who smoke are much less likely to have significant obstruction upon cardiac imaging and that substance use treatment may be underutilized in those with CHD.https://www.tandfonline.com/doi/10.1080/15592294.2024.2433833DNA methylationalcoholismheavy alcohol usedigital PCRepigeneticscoronary heart disease |
| spellingShingle | Allan Andersen Steven R. H. Beach Willem Philibert James A. Mills Emily Milefchik Emma Papworth Kelsey Dawes Joanna Moody Gracie Weeks Ellyse Froehlich Kaitlyn deBlois Jeffrey D. Long Ferhaan Ahmad Robert Philibert Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome Epigenetics DNA methylation alcoholism heavy alcohol use digital PCR epigenetics coronary heart disease |
| title | Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome |
| title_full | Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome |
| title_fullStr | Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome |
| title_full_unstemmed | Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome |
| title_short | Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome |
| title_sort | heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome |
| topic | DNA methylation alcoholism heavy alcohol use digital PCR epigenetics coronary heart disease |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2024.2433833 |
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