Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population
ObjectiveTo investigate the association between the Chinese visceral adiposity index(CVAI) and the risk of stroke incidence in middle-aged and older adults (≥45 years) using data from the China Health and Retirement Longitudinal Study (CHARLS).MethodsData from the 2015, 2018, and 2020 CHARLS surveys...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-01-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0540 |
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| author | SHAO Miaomiao CHEN Zhengzhen |
| author_facet | SHAO Miaomiao CHEN Zhengzhen |
| author_sort | SHAO Miaomiao |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between the Chinese visceral adiposity index(CVAI) and the risk of stroke incidence in middle-aged and older adults (≥45 years) using data from the China Health and Retirement Longitudinal Study (CHARLS).MethodsData from the 2015, 2018, and 2020 CHARLS surveys were analyzed, focusing on middle-aged and older adults. The primary outcome was the occurrence of new stroke events (including both hemorrhagic and ischemic strokes) during the follow-up period. Covariates included general demographic characteristics, lifestyle factors, health status, and blood biomarkers. Cox proportional hazards regression models were used to explore the dose-response relationship between CVAI and stroke risk.ResultsA total of 11 432 middle-aged and older adults were included, with a mean age of 60.24±9.56 years. Among them, 6157 (53.86%) were women and 5275(46.14%) were men. Over a median follow-up period of 5 years, 905 individuals(7.92%, 905/11 432) experienced a stroke. After adjusting for demographic and lifestyle covariates, each interquartile range (IQR) increase in CVAI was associated with a 28% higher risk of stroke (HR=1.28, 95% CI: 1.20-1.36). Compared to the first quartile (Q1), the third (Q3: HR=1.60, 95% CI: 1.30-1.97) and fourth quartiles (Q4: HR=2.02, 95% CI: 1.65-2.47) were significantly associated with an increased risk of stroke. Interaction analysis revealed a significant interaction between CVAI and gender (Pfor interaction < 0.001). Restricted cubic spline analysis demonstrated a non-linear relationship between CVAI and stroke risk (Pnonlinear=0.005).ConclusionsHigher CVAI levels are associated with an increased risk of stroke. CVAI serves as an effective biomarker for identifying individuals at high risk of stroke and can inform primary stroke prevention strategies. |
| format | Article |
| id | doaj-art-3ca21ba7dd4c4f7fa55d95016e55c405 |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-3ca21ba7dd4c4f7fa55d95016e55c4052025-08-20T04:00:28ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-01-0116492292910.12290/xhyxzz.2024-0540Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese PopulationSHAO Miaomiao0CHEN Zhengzhen1Renji college of Wenzhou Medical University, Wenzhou, Zhejiang 325035, ChinaRenji college of Wenzhou Medical University, Wenzhou, Zhejiang 325035, ChinaObjectiveTo investigate the association between the Chinese visceral adiposity index(CVAI) and the risk of stroke incidence in middle-aged and older adults (≥45 years) using data from the China Health and Retirement Longitudinal Study (CHARLS).MethodsData from the 2015, 2018, and 2020 CHARLS surveys were analyzed, focusing on middle-aged and older adults. The primary outcome was the occurrence of new stroke events (including both hemorrhagic and ischemic strokes) during the follow-up period. Covariates included general demographic characteristics, lifestyle factors, health status, and blood biomarkers. Cox proportional hazards regression models were used to explore the dose-response relationship between CVAI and stroke risk.ResultsA total of 11 432 middle-aged and older adults were included, with a mean age of 60.24±9.56 years. Among them, 6157 (53.86%) were women and 5275(46.14%) were men. Over a median follow-up period of 5 years, 905 individuals(7.92%, 905/11 432) experienced a stroke. After adjusting for demographic and lifestyle covariates, each interquartile range (IQR) increase in CVAI was associated with a 28% higher risk of stroke (HR=1.28, 95% CI: 1.20-1.36). Compared to the first quartile (Q1), the third (Q3: HR=1.60, 95% CI: 1.30-1.97) and fourth quartiles (Q4: HR=2.02, 95% CI: 1.65-2.47) were significantly associated with an increased risk of stroke. Interaction analysis revealed a significant interaction between CVAI and gender (Pfor interaction < 0.001). Restricted cubic spline analysis demonstrated a non-linear relationship between CVAI and stroke risk (Pnonlinear=0.005).ConclusionsHigher CVAI levels are associated with an increased risk of stroke. CVAI serves as an effective biomarker for identifying individuals at high risk of stroke and can inform primary stroke prevention strategies.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0540chinese visceral adiposity indexstrokemiddle-aged and elderlyprospective associationdisease prevention |
| spellingShingle | SHAO Miaomiao CHEN Zhengzhen Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population Xiehe Yixue Zazhi chinese visceral adiposity index stroke middle-aged and elderly prospective association disease prevention |
| title | Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population |
| title_full | Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population |
| title_fullStr | Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population |
| title_full_unstemmed | Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population |
| title_short | Prospective Association Between Chinese Visceral Adiposity Index and Risk of Stroke Incidence in Middle-aged and Elderly Chinese Population |
| title_sort | prospective association between chinese visceral adiposity index and risk of stroke incidence in middle aged and elderly chinese population |
| topic | chinese visceral adiposity index stroke middle-aged and elderly prospective association disease prevention |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0540 |
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