An ultrasonic degraded polysaccharide extracted from Pueraria lobata ameliorate ischemic brain injury in mice by regulating the gut microbiota and LPS-TLR4 pathway

An ultrasonic degraded polysaccharide extracted from Pueraria lobata ameliorate ischemic brain injury in mice by regulating the gut microbiota and LPS-TLR4 pathway

Ischemia brain injury is closely associated with the gut microbiota. Polysaccharides, as a typical prebiotic, have been extensively employed in stroke treatment. In our previous study, Pueraria lobata polysaccharide (PLP-3) with antioxidant activity was prepared via water extraction and alcohol prec...

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Bibliographic Details
Main Authors: Yulong Zhang, Zuman Dou, Shanshan Li, Huaying Zhang, Shanshui Zeng, Xiangyu Zuo, Yu Xiao, Lingling Zhang, Zhixin Li, Qingfeng Zhu, Wenyang Zhang, Hui Niu, Qingfei Duan, Xiaoxia Chen, Zhuang Li, Hongwei Zhou, Qian Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ultrasonics Sonochemistry
Subjects:
Ultrasonic degradation
Pueraria lobata polysaccharide
Ischemic brain injury
Gut microbiota
LPS/TLR4/MyD88 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1350417724004498
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