Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation
Purple sweet potatoes are recognized for their prebiotic properties including againts Lactobacillus casei and L. bulgaricus bacteria. This prebiotic effect is due to the high starch content in purple sweet potatoes. The amylose content in starch which is difficult to digest in gastointestinal tract,...
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| Language: | English |
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Universitas Ahmad Dahlan
2025-07-01
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| Series: | Pharmaciana |
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| Online Access: | https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/29581 |
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| author | Umi Yuniarni Ratih Aryani Bertha Rusdi Qori Nabilla |
| author_facet | Umi Yuniarni Ratih Aryani Bertha Rusdi Qori Nabilla |
| author_sort | Umi Yuniarni |
| collection | DOAJ |
| description | Purple sweet potatoes are recognized for their prebiotic properties including againts Lactobacillus casei and L. bulgaricus bacteria. This prebiotic effect is due to the high starch content in purple sweet potatoes. The amylose content in starch which is difficult to digest in gastointestinal tract, functions as a prebiotic. To enhance the prebiotic effect of purple sweet potato starch, modification into resistant starch can be performed. Resistant starch exhibits a higher prebiotic effect compared to regular starch because it cannot be broken down by digestive enzymes, allowing it to reach the large intestine in significant amounts. Additionally, the prebiotic effect can be further enhanced by creating mucoadhesive granule formulations that increase the contact time of a substance on the mucosa of the digestive tract. This study aims to evaluate the prebiotic effect of resistant starch from purple sweet potatoes and to develop its mucoadhesive granule formulation. The resistant starch from purple sweet potatoes was prepared using the heat moisture treatment method. The prebiotic activity of resistant starch was tested against Lactobacillus acidophilus and Escherichia coli. The granule formulation was prepared by varying the concentration of polymers used, namely a combination of HPMC and carbopol as mucoadhesive polymers. The results showed that resistant starch from purple sweet potatoes had a prebiotic index of 0.930. The granule formulation F3 with an HPMC and Carbopol polymer ratio of 1:2 was identified as a good mucoadhesive granule formulation. It met pharmaceutical evaluation with a mucoadhesive percentage value of 40%. |
| format | Article |
| id | doaj-art-3c47eeadee0c4e3e984d7a9ef048fdbf |
| institution | Kabale University |
| issn | 2088-4559 2477-0256 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Universitas Ahmad Dahlan |
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| series | Pharmaciana |
| spelling | doaj-art-3c47eeadee0c4e3e984d7a9ef048fdbf2025-08-20T03:44:40ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562025-07-0115221022010.12928/pharmaciana.v15i2.2958121243Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulationUmi Yuniarni0Ratih Aryani1Bertha Rusdi2Qori Nabilla3Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Universitas Islam BandungPharmacy Study Program, Faculty of Mathematics and Natural Sciences, Universitas Islam BandungPharmacist professional Education Study Program, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Purple sweet potatoes are recognized for their prebiotic properties including againts Lactobacillus casei and L. bulgaricus bacteria. This prebiotic effect is due to the high starch content in purple sweet potatoes. The amylose content in starch which is difficult to digest in gastointestinal tract, functions as a prebiotic. To enhance the prebiotic effect of purple sweet potato starch, modification into resistant starch can be performed. Resistant starch exhibits a higher prebiotic effect compared to regular starch because it cannot be broken down by digestive enzymes, allowing it to reach the large intestine in significant amounts. Additionally, the prebiotic effect can be further enhanced by creating mucoadhesive granule formulations that increase the contact time of a substance on the mucosa of the digestive tract. This study aims to evaluate the prebiotic effect of resistant starch from purple sweet potatoes and to develop its mucoadhesive granule formulation. The resistant starch from purple sweet potatoes was prepared using the heat moisture treatment method. The prebiotic activity of resistant starch was tested against Lactobacillus acidophilus and Escherichia coli. The granule formulation was prepared by varying the concentration of polymers used, namely a combination of HPMC and carbopol as mucoadhesive polymers. The results showed that resistant starch from purple sweet potatoes had a prebiotic index of 0.930. The granule formulation F3 with an HPMC and Carbopol polymer ratio of 1:2 was identified as a good mucoadhesive granule formulation. It met pharmaceutical evaluation with a mucoadhesive percentage value of 40%.https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/29581resistant starch, purple sweet potato, prebiotic, mucoadhesive granule, ipomoea batatas, |
| spellingShingle | Umi Yuniarni Ratih Aryani Bertha Rusdi Qori Nabilla Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation Pharmaciana resistant starch, purple sweet potato, prebiotic, mucoadhesive granule, ipomoea batatas, |
| title | Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation |
| title_full | Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation |
| title_fullStr | Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation |
| title_full_unstemmed | Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation |
| title_short | Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation |
| title_sort | prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation |
| topic | resistant starch, purple sweet potato, prebiotic, mucoadhesive granule, ipomoea batatas, |
| url | https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/29581 |
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